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- 2025年07月16日
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一种膜活性肽抗生素，属于peptaibol类，可强烈诱导螺旋肽结构并在细胞膜的脂质双层中形成电压门控离子通道；常用于研究离子通道组装、电压门控和肽-膜相互作用以及诱导植物的防御反应A membrane active peptide antibiotic of the peptaibol class that strongly induces helical peptide structures and forms voltage-gated ion channels in the lipid bilayers of cell membranes; often used to study ion channel assembly, voltage gating, and peptide-membrane interactions as well as to induce defense responses in plants.
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文献和实验相关实验
Metabolic Assessment in Alamethicin-Activated Liver Microsomes: Co-activating CYPs and UGTs
The methods and materials described in this chapter are for a medium throughput screening assay for the study of parallel CYP- and UGT-mediated metabolic pathways in microsomes. Alamethicin, a pore-forming peptide, was used to activate UGTs
, lateral diffusion of two fluorescently-labelled voltage-dependent pore-forming peptides (alamethicin and S4s from Shaker K+ channel) was determined at rest and in the conducting state. This study demonstrates the feasibility of such experiments with PLBs
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Alamethicin
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