COX Inhibitor Pack

CaymanCOX抑制剂包含有常用的环氧合酶(COX)抑制剂的组合。每个试剂盒均含有阿司匹林，即典型的非选择性、不可逆COX抑制剂。COX-PAK中含有一系列COX-2选择性抑制剂，包括NS-398，这是最早报道且使用最广泛的抑制剂之一。另一种COX-2选择性抑制剂是CAY10404，其COX-2选择性几乎提高了500,000倍。强效COX-1选择性抑制剂SC-560是一种可逆的二芳基杂环COX-1抑制剂，活性低nM。还包括戊酰水杨酸酯，它是COX酶的不可逆烷基化剂，对COX-1具有一定的选择性。白藜芦醇也包含在COX-PAK中，因为它具有复杂的活性，包括COX抑制、过氧化物酶抑制、抗氧化活性和基因监管。The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype nonselective, irreversible COX inhibitor. A series of COX-2 selective inhibitors are available in the COX-PAK, including NS-398, one of the first reported and most widely used. Another COX-2-selective inhibitor included is CAY10404, with nearly 500,000-fold COX-2 selectivity. The potent COX-1-selective inhibitor SC-560 is an example of a reversible, diaryl heterocycle COX-1 inhibitor with low nM activity. Also included is valeroyl salicylate, an irreversible alkylator of COX enzymes with some selectivity toward COX-1. Resveratrol is also included in the COX-PAK due to its complex activities, which include COX inhibition, peroxidase inhibition, antioxidant activity, and gene regulation.