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文献和实验on COX-1. It is hypothesized that a selective COX-2 inhibitor will achieve therapeutic efficacy in osteoarthritis, rheumatoid arthritis, and pain management while substantially improved gastrointestinal toxicity profile owing to its COX-2 selectivity
dream_reloaded A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold
Comparison of Protein Expression by Isotope-Coded Affinity Tag Labeling
for the celecoxib-regulated proteins in a colon cancer cell line. Celecoxib, a cyclooxygenase-2 (COX-2) specific inhibitor, is used as a colorectal cancer preventative drug in clinical trials. Here, celecoxib is used to inhibit the expression of COX-2 in a colon
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