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CaMKII (Phospho-Thr286/Thr287)

Monoclonal Antibody (Clone 22B1)
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  • 2025年07月13日
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    抗原:小鼠重组CaMKII;宿主:小鼠,克隆22B1;同种型:IgG1;交叉反应性:(+)大鼠CaMKII;应用:ELISA、IF、IP和WB;CaMKII在神经突触刺激和T细胞受体信号传导中发挥作用。Ca2+/钙调蛋白与其调节域的结合释放了其自身抑制作用并激活了激酶。这种激酶激活导致Thr286处的自身磷酸化。PP1在Thr286处使磷酸化CaMKII去磷酸化,而PKA阻止了这种去磷酸化。Antigen: mouse recombinant CaMKII; Host: mouse, clone 22B1; Isotype: IgG1; Cross Reactivity: (+) rat CaMKII; Application(s): ELISA, IF, IP, and WB; CaMKII functions in neural synaptic stimulation and T-cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.

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