AMP-Deoxynojirimycin

一种去氧诺吉霉素的疏水性衍生物，能够强效抑制β-葡萄糖苷酶2（IC50 = 0.3 nM），较弱地拮抗葡萄糖神经酰胺合成酶（IC50 = 25 nM），但对其他GCase同种型的抑制作用较差；抑制致敏物引起的结肠炎，增强胰岛素敏感性，并诱导SREBP调控的基因表达和胆固醇合成。A hydrophobic derivative of deoxynojirimycin that potently inhibits β-glucosidase 2 (IC50 = 0.3 nM), less potently antagonizes glucosylceramide synthase (IC50 = 25 nM), but only poorly inhibits other GCase isoforms; suppresses hapten-induced colitis, enhances insulin sensitivity, and induces SREBP-regulated gene expression and cholesterol synthesis.