2,3,5,4'-Tetrahydroxyl-dipheny

一种具有多种生物活性的二苯乙烯葡萄糖苷；在无细胞测定中清除DPPH自由基（IC50=40µM）；抑制阿霉素诱导的小鼠心肌细胞凋亡、线粒体膜电位丧失和ROS生成；在30、60和120mg/kg剂量下增加由饮食诱发的动脉粥样硬化大鼠模型分离的主动脉环乙酰胆碱诱导的松弛和NO水平；在15a剂量下减少由MCAO诱发的缺血和再灌注损伤小鼠模型中的梗塞面积和神经元凋亡。A stilbene glucoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 40 µM); inhibits doxorubicin-induced apoptosis, loss of mitochondrial membrane potential, and generation of ROS in mouse cardiomyocytes; increases acetylcholine-induced relaxation of, and NO levels in, aortic rings isolated from a rat model of diet-induced atherosclerosis at 30, 60, and 120 mg/kg; reduces infarct area and neuronal apoptosis in a mouse model of MCAO-induced ischemia and reperfusion injury at 15a.分子式C20H22O9分子量406.4OC(C=C1)=CC=C1/C=C/C(C=C(C=C2O)O)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO