(+)-AS 115

KIAA1363的强效选择性灭活剂的单一对映体，KIAA1363是一种MAGE水解酶，该酶在来自各种组织的侵袭性癌症中上调（在SK0V-3细胞中作为外消旋混合物测试时，IC50=150nM）；AS115的各个对映体的活性，即(+)-AS115和(−)-AS115，尚未确定A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in aggressive cancers from various tissues (IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e,. (+)-AS 115 and (−)-AS 115, has not been determined.