(−)-L-threo-PDMP (hydrochlorid

一种促使神经酰胺糖苷合成的增强剂；在酶分析中，分别在5 µM和2.5 µM浓度下使葡糖基神经酰胺合酶活性提高4%和8%；增加神经酰胺GM3、GD3和GQ1b合成酶的活性，并提高B16黑色素瘤细胞中的葡糖基神经酰胺、乳糖基神经酰胺和神经酰胺GM3水平；抑制MCF-7、MDA-MB-468、SK-BR-3细胞的生长（IC50分别为4、7和6 µM）；在体外增加神经突起生长和突触形成，并在大鼠缺血后每日40 mg/kg剂量提高长期记忆的保持能力。An enhancer of ganglioside biosynthesis; increases glucosylceramide synthase activity by 4 and 8% at 5 and 2.5 µM, respectively, in an enzyme assay; increases the activity of ganglioside GM3, GD3, and GQ1b synthases and increases the levels of glucosylceramide, lactosylceramide, and ganglioside GM3 in B16 melanoma cells; inhibits the growth of MCF-7, MDA-MB-468, SK-BR-3 cells (IC50s = 4, 7, and 6 µM, respectively); increases neurite outgrowth and synapse formation in vitro and improves retention of a long-term memory learned prior to forebrain ischemia in rats at 40 mg/kg per day following ischemia.