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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human Interleukin-15 (IL15)
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
20μg
英文名称:
Recombinant Human Interleukin-15 (IL15)品名简称:
Recombinant Human IL15 protein货号:
CSB-EP011593HU规格:
20μg价格:
1344LC-MS/Western Blot:
/SDS-PAGE:
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.纯度:
Greater than 90% as determined by SDS-PAGE.内毒素:
Not test生物活性:
/基因名:
IL15Uniprot No.:
P40933别名:
IL 15; IL-15; IL15; IL15_HUMAN; Interleukin 15; Interleukin-15; Interleukin15; MGC9721种属:
Homo sapiens (Human)蛋白长度:
Full Length of Mature Protein来源:
E.coli分子量:
16.8 kDa表达区域:
49-162aa氨基酸序列:
NWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS蛋白标签:
N-terminal 6xHis-tagged产品提供形式:
Liquid or Lyophilized powder缓冲液:
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
3-7 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.功能2:
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.文献:
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.Grabstein K.H., Eisenman J., Shanebeck K., Rauch C., Srinivasan S., Fung V., Beers C., Richardson J., Schoenborn M.A., Ahdieh M., Johnson L., Alderson M.R., Watson J.D., Anderson D.M., Giri J.G.Science 264:965-968(1994)研究领域:
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文献和实验Interleukin 15 (IL-15) has been described as a cytokine with biologic functions similar to those of IL-2. IL-2 and IL-15 utilize a receptor composed of three subunits: IL-2 receptor β-chain, the y-chain (βc) shared by IL-15, IL-2, IL-4, IL-
遗传疾病Muckle-Well 综合征相关的慢性炎症,这种疾病是由NLRP3基因突变引起的。其中一个检测方法是脾脏的大小——脾脏越大,炎症就越多。Muckle-Well 综合征小鼠脾脏平均比正常小鼠大两倍,但经ChoK抑制剂处理后脾脏大小恢复正常。NLRP3炎症小体促进炎症,因为它会触发释放两种称为细胞因子的非常有效的促炎分子的释放:白细胞介素IL-1和IL-18。根据Karin的说法,现有的药物可以阻断IL-1但不能阻断IL-18。他的团队发现,ChoK抑制剂可以降低这两种细胞因子。“有几种疾病
近几年,以 T 细胞为靶点的免疫治疗策略的研究一直居于肿瘤免疫治疗研究热点榜高位,当大家都想在这个领域分一杯羹时,新的尝试开始逐渐挤入热度的核心,其中不乏以 NK 细胞为靶点的治疗方法的探索。与 T 细胞的研究相比,NK 细胞相关研究出了「抄作业」之外,还有什么特殊之处呢? IL15 是 NK 细胞发育所必须的细胞因子 NK 细胞又称自然杀伤细胞,属于天然免疫系统的核心细胞,是机体内重要的免疫细胞。NK 细胞是人体抵抗癌细胞和病毒感染的第一道防线,可非特异性直接杀伤肿瘤细胞,这种天然杀伤
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