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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
L-651582 Orotate; CAI Orotate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
187739-60-2
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥650.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1600.0 |
| 规格： | 10 mg | 产品价格： | ￥2400.0 |
| 规格： | 25 mg | 产品价格： | ￥4100.0 |
| 规格： | 50 mg | 产品价格： | ￥5800.0 |
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Carboxyamidotriazole Orotate
CAS No. : 187739-60-2
MCE 国际站：Carboxyamidotriazole Orotate
产品活性：Carboxyamidotriazole Orotate (L-651582 Orotate)，是一种口服生物有效的信号转导抑制剂Carboxyamidotriazole (CAI) 的 orotate 盐形式。Carboxyamidotriazole Orotate 是一种非电压性钙通道 (nonvoltage-operated calcium channels) 和钙通道介导的信号通路 (calcium channel-mediated signaling pathways) 的细胞抑制剂，具有抗癌，抗炎活性和抗血管生成作用。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：Calcium Channel
In Vitro: Carboxyamidotriazole Orotate (0.1-10 µM; 24-96 hours) inhibits cell proliferation of LAMA84R and K562R cell lines.
Carboxyamidotriazole Orotate inhibits the phosphorylation of a selected target of Bcr-Abl kinase. Tyrosine phosphorylation of CrkL is reduced by 5 µM Carboxyamidotriazole Orotate treatment.
In Vivo: Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts.
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