Tavapadon,1643489-24-0

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Tavapadon

CAS No. : 1643489-24-0

MCE 国际站：Tavapadon

产品活性：Tavapadon (PF-06649751) 是一种具有口服活性，高选择性的多巴胺 D1/D5 受体部分激动剂。Tavapadon 可有效促进运动并减少残疾，具有用于帕金森氏病的潜力。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor

In Vivo: Tavapadon (PF-06649751; 0.02 and 0.04 mg/kg; s.c.) at the 0.04 mg/kg test dose increases locomotor activity, whereas the 0.02 mg/kg dose has little or no effect.
Tavapadon (0.04 mg/kg, s.c.) also improves parkinsonian disability scores with the maximal improvement observed at 110 min after drug administration.
Higher doses of Tavapadon (0.1 and 0.15 mg/kg; s.c.) leads to statistically significant improvement relative to vehicle in locomotor activity.
Tavapadon (0.1 mg/kg; s.c.) has the mean maximal unbound plasma concentration of 8 nM and achieves 3 hours after compound administration in captive-bred macaques.

相关产品：Clozapine N-oxide  |  MPTP hydrochloride  |  Oxidopamine hydrobromide  |  Chlorpromazine hydrochloride  |  L-DOPA  |  Dopamine hydrochloride  |  SCH-23390 hydrochloride  |  Haloperidol  |  SKF 38393 hydrochloride  |  Pimozide  |  Cabergoline  |  Bromocriptine mesylate  |  Risperidone  |  Olanzapine  |  Thioridazine hydrochloride  |  Brexpiprazole  |  Aripiprazole  |  Fluphenazine dihydrochloride  |  Sulpiride  |  Flunarizine dihydrochloride  |  ONC206  |  WAY-100635 maleate  |  Quetiapine  |  Trifluoperazine dihydrochloride  |  Lurasidone  |  Nuciferine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds