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- 2025年12月05日
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1818885-54-9
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AR antagonist 1
CAS No. : 1818885-54-9
MCE 国际站：AR antagonist 1
产品活性：AR antagonist 1 (compound 29) 是一种有效的 AR 拮抗剂，与 E3 连接酶配体结合，与 VHL 蛋白结合亲和力较弱，用于合成PROTAC ARD-266 (HY-133020)。
研究领域：PROTAC
作用靶点：Ligands for E3 Ligase | Ligands for Target Protein for PROTAC
In Vitro: AR antagonist 1 (compound 29) is the ligand for target ligase of ARD-266. ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader.
AR antagonist 1 exhibits micromolar binding affinity to its E3 ligase complex, it can be successfully employed for the design of highly potent and efficient PROTAC degraders.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
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文献和实验Detection of Ligand-Selective Interactions of the Human Androgen Receptor by SELDI-MS-TOF
in the presence of antagonist which is verified by a protein–protein interaction assay in vivo. This scheme can provide further insights into the molecular mechanisms of AR ligand selectivity.
Automated Microscopy and Image Analysis for Androgen Receptor Function
Systems-level approaches have emerged that rely on analytical, microscopy-based technology for the discovery of novel drug targets and the mechanisms driving AR signaling, transcriptional activity, and ligand independence. Single cell
的分子，如CD2、CD4、CD8、CD28、CD31、CD50、CD54、CD56、CD58、CD80、CD102、CD106等。 （5）有CD命名的CR有CR1（CD35）、CR2（CD21）、CR3（CD11b\CD18）、CR4（CD11c/CD18）和C5aR(CD88)，其中CR3和CR4属于粘附分子中整合素超家族成员。 （6）有CD编号的CKR有CD115～CDw130；属于IGSF结构的CKR有CD115、CD
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