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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1818885-55-0
- 规格：
10 mM * 1 mL/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥385.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥350.0 |
| 规格： | 25 mg | 产品价格： | ￥665.0 |
| 规格： | 50 mg | 产品价格： | ￥1085.0 |
| 规格： | 100 mg | 产品价格： | ￥1750.0 |
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AR antagonist 1 hydrochloride
CAS No. : 1818885-55-0
MCE 国际站：AR antagonist 1 hydrochloride
产品活性：AR antagonist 1 (compound 29) hydrochloride 是一种有效的 AR 拮抗剂，与 E3 连接酶配体结合，与 VHL 蛋白结合亲和力较弱，用于合成 PROTAC ARD-266 (HY-133020)。
研究领域：PROTAC | Vitamin D Related/Nuclear Receptor
作用靶点：Ligands for E3 Ligase | Ligands for Target Protein for PROTAC | Androgen Receptor
In Vitro: AR antagonist 1 (compound 29) hydrochloride is the ligand for target ligase of ARD-266. ARD-266 is a highly potent and VHL E3 ligase-based?androgen receptor (AR)?PROTAC degrader.
AR antagonist 1 exhibits micromolar binding affinity to its E3 ligase complex, it can be successfully employed for the design of highly potent and efficient PROTAC degraders.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
相关产品：Bioactive Compound Library Plus | Anti-Cancer Compound Library | Ubiquitination Compound Library | Transcription Factor-Targeted Library | Anti-Prostate Cancer Compound Library | Nuclear Receptor Compound Library | E3 Ligase Ligand Library | Target Protein Ligand Library | Enzalutamide | (+)-JQ-1 | Ibrutinib | DHEA | Lenalidomide | Pomalidomide | Bavdegalutamide | CC-885 | Quizartinib | Eragidomide | Iberdomide | Medroxyprogesterone acetate | Thalidomide | VH-298 | Apalutamide | Darolutamide | Bicalutamide | Spironolactone | Flutamide | VH032 | Danazol | Lupeol | ARCC-4 | 11-Ketodihydrotestosterone | SI-109 | ALV2 | Ailanthone | Cemsidomide | (S,R,S)-AHPC monohydrochloride | (S,S,S)-AHPC hydrochloride
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
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