MAP4K4-IN-3,1811510-58-3

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MAP4K4-IN-3

CAS No. : 1811510-58-3

MCE 国际站：MAP4K4-IN-3

产品活性：MAP4K4-IN-3 (Compound 17) 是一种有效的选择性 MAP4K4 抑制剂，在激酶实验中 IC₅₀ 为 14.9 nM，在细胞实验中 IC₅₀ 为 470 nM。具有抗糖尿病活性。

研究领域：MAPK/ERK Pathway

作用靶点：MAP4K

In Vitro: MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic agents.

In Vivo: Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4°C) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3.

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