N-（32-亚油酰氧基-邻苯二甲t酰基）-鞘氨醇-D9|N-

N-（32-亚油酰氧基-邻苯二甲t酰基）-鞘氨醇-D9，N-(32-Linoleoyloxy-dotriacontanoyl)-sphingosine-D9，Hydroxytetracosanoyl phytosphingosine

产品名称：N-（32-亚油酰氧基-邻苯二甲t酰基）-鞘氨醇-D9-N-(32-Linoleoyloxy-dotriacontanoyl)-sphingosine-D9

产品货号：2208-1

产品规格：1mg

背景资料：This product is a high purity omega-esterified ceramide that is ideal as a standard and for studies involving skin-barrier lipids. Omega-esterified ceramides are found almost exclusively in the epidermal layer, especially the stratum corneum. The stratum corneum is the outermost cellular layer of the epidermis and functions as the permeability barrier in mammals. It contains 12 extractable ceramide fractions containing sphingosine, 6-hydroxysphingosine, dihydrosphingosine and phytosphingosine bases.1,2 The omega-esterified ceramides are formed from glucosylceramide and sphingomyelin in special lamellar bodies in epidermal cells from which they are excreted into the extracellular domain of the outermost cell layer of the epidermis. Mammalian skin contains significant amounts of sphingolipids (as much as 50% of the total lipids), particularly very long chain linoleoyl esterified ceramide and glucosylceramide (also called O-acylceramide and O-acylglucosylceramide). These lipids, which are mostly found in the extracellular domains, are vital to the water permeability barrier to prevent lethal loss of water and pathogen invasion. The omega-esterified ceramides can be covalently bound to proteins of the cornified envelope where they form a hydrophobic layer. A deficiency of linoleoyl omega-esterified ceramides is strongly correlated with skin diseases such as psoriasis and atopic dermatitis.3

保存建议：N-（32-亚油酰氧基-邻苯二甲t酰基）-鞘氨醇-D9-N-(32-Linoleoyloxy-dotriacontanoyl)-sphingosine-D9对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：EOS Ceramide, deuterated|O-acylceramide, deuterated

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