N-ω-CD3-十八碳酰基-D-赤型-鞘氨醇-1-磷酸|N-

N-ω-CD3-十八碳酰基-D-赤型-鞘氨醇-1-磷酸，N-omega-CD3-Octadecanoyl-D-erythro-sphingosine-1-phosphate，N-omega-CD3-Octadecanoyl-D-erythro-sphingosine-1-phosphate

产品名称：N-ω-CD3-十八碳酰基-D-赤型-鞘氨醇-1-磷酸-N-omega-CD3-Octadecanoyl-D-erythro-sphingosine-1-phosphate

产品货号：2206-1

产品规格：1mg

背景资料：This deuterated ceramide-1-phosphate is ideal as a mass spectrometry standard and for in vivo and in vitro investigations. Ceramide-1-phosphate is one of several important phosphosphingolipids in mammalian cells and it is generated by the phosphorylation of ceramide by the enzyme ceramide kinase. Ceramide-1-phosphate is currently attracting much attention in research due to its important cellular functions like its role in inflammation, as a novel second messenger, and its involvement in cellular processes like phagocytosis, potassium channel function, inflammatory responses, cell survival, and tumorigenesis. The first reported biological action of ceramide-1-phosphate was its ability to stimulate DNA synthesis and cell division. Ceramide-1-phosphate was also found to be mitogenic for both fibroblasts and macrophages. The mitogenic effect of ceramide-1-phosphate is dependent on its intracellular ability to stimulate reactive oxygen specie production in macrophages via the enzyme NADPH oxidase. This enzyme is downstream of PKC-α and cPLA(2)-α in this pathway. Another important function of ceramide-1-phophate is its promotion of cell survival. Ceramide-1-phosphate stimulates the phosphatidylinositol 3-kinase (PI3-K)/protein kinase B (PKB) pathway, a major mechanism whereby growth factors promote cell survival. It is probable that ceramide-1-phosphate blocks apoptosis by stimulating the PI3-K/PKB/NFkappaB pathway and thereby maintaining the production of antiapoptotic Bcl-X(L). Based on these and previous findings it has been proposed that the inhibition of acid sphingomyelinase and the subsequent decrease in ceramide levels would allow cell signaling through stimulation of the PI3-K/PKB pathway to promote cell survival.

保存建议：N-ω-CD3-十八碳酰基-D-赤型-鞘氨醇-1-磷酸-N-omega-CD3-Octadecanoyl-D-erythro-sphingosine-1-phosphate对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：C18:0-D3-Ceramide-1-phosphate|N-Stearoyl-D3-C1P

点击：N-ω-CD3-十八碳酰基-D-赤型-鞘氨醇-1-磷酸-N-omega-CD3-Octadecanoyl-D-erythro-sphingosine-1-phosphate查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询艾美捷科技有限公司。更多Matreya公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。

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