N-糖化半乳糖基鞘氨醇|N-Glycinated galac

N-糖化半乳糖基鞘氨醇，N-Glycinated galactosylsphingosine，N-Glycinated galactosylsphingosine

产品名称：N-糖化半乳糖基鞘氨醇-N-Glycinated galactosylsphingosine

产品货号：2091-1

产品规格：1mg

背景资料：N-Glycinated galactosylsphingosine is an analogue of the important biomolecule galactosylsphingosine (psychosine). It is ideal for use as an internal standard in the extraction and mass spectrometry analysis of galactosylsphingosine from natural samples.1 The free amine group gives this product very similar physical characteristics to the natural glycolipid while the glycine adds an additional 57 units to the molecule making it easy to detect by mass spectroscopy. Galactosylceramides are found primarily in neuronal tissues and are the major glycosphingolipids in the central nervous system. They constitute the largest single component of the myelin sheath of nerves and act, along with other components, to form part of the structural support of the myelin sheath.2 They are involved in a very wide range of biological activities such as cell agglutination, intracellular communication, cellular development, and antitumor/cytotoxic effects.3 Galactosylceramides can be metabolized into sulfatide which is also abundant in the nervous system and myelin sheaths. Krabbe disease is a demyelinating disease caused by a lack of the enzyme galactosylceramidase.4 This deficiency results in the accumulation of galactosylceramide and galactosylsphingosine in cells, making both of these lipids potentially useful biomarkers in Krabbe disease diagnosis.4 Galactosylsphingosine is highly cytotoxic and cannot be degenerated further in Krabbe cells due to the lack of galactosylceramidase. Although GM1 gangliosidase can degrade galactosylceramide it cannot degrade galactosylsphingosine. Galactosylsphingosine can cause oligodendrocyte death, astrocyte activation and the formation of multinuclear globoid-like cells. It is present naturally in small amounts and has a role in the sphingosine-1- phosphate receptor superfamily. Galactosylsphingosine has been found to induce cell apoptosis, cytokine activation, phospholipase activation, peroxisomal dysfunction, and altered calcium homeostasis.5

保存建议：N-糖化半乳糖基鞘氨醇-N-Glycinated galactosylsphingosine对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：N-Glycinated cerebroside|N-Glycinated galactosylceramide|N-Glycinated psychosine

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