N-糖化乳糖基鞘氨醇|N-Glycinated lactos

N-糖化乳糖基鞘氨醇，N-Glycinated lactosylsphingosine，N-Glycinated lactosylsphingosine

产品名称：N-糖化乳糖基鞘氨醇-N-Glycinated lactosylsphingosine

产品货号：2090-1

产品规格：1mg

背景资料：N-Glycinated lactosylsphingosine is an analogue of the important biomolecule lactosylsphingosine. It is ideal for use as an internal standard in the extraction and mass spectrometry analysis of lactosylsphingosine from natural samples.(1) The free amine group gives this product very similar physical characteristics to the natural glycosphingolipid while the glycine adds an additional 57 units to the molecule making it easy to detect by MS. Lactosylceramide is the precursor of many other glycosphingolipids and also functions as a second messenger and protein receptor, making it a very important biochemical. Many cellular processes are dependent on lactosylceramide since it is the substrate for neutral oligoglycosylceramides and gangliosides, all of which have their own vital functions. Lactosylceramide also helps to stabilize the lipid membrane, activate receptor molecules and act as a receptor for certain bacteria and toxins. In animals, where it is found mostly in epithelial and neuronal cells, it is expressed on neutrophils and macrophages, where it binds to toxins and bacteria, which are then engulfed and eliminated. It's role as a second messenger has been found to be vital and dysfunctions in its processes can lead to cancer and inflammation due to it being critical for neutrophil activity and in activating anti-inflammatory responses.(2) Therefore, it is being studied for its use in cancer therapies and as a therapy for other diseases. Other examples of lactosylceramide second messenger functions are tumor necrosis factor α and platelet-derived growth factor. Niemann-Pick Type C, a neurovisceral lysosomal cholesterol trafficking and lipid storage disorder, leads to an accumulation of multiple lipids, including excess unesterified cholesterol, GM2 and GM3 gangliosides, lactosylceramide, and glucosylceramide.(3) Lactosylceramide is also important in the activation of platelet/endothelial cell adhesion molecule-1 which causes adhesion and diapedesis of monocytes/lymphocytes.(4) In animals neutral lyso-glycosphingolipids occur naturally in small amounts. lyso-Lactosylceramide can release calcium stores from microsomes in the brain cortex and cerabellum.(5) Other lyso-glycosphingolipids also release calcium but in a mechanism different from lyso-lactosylceramide.

保存建议：N-糖化乳糖基鞘氨醇-N-Glycinated lactosylsphingosine对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：N-Glycinated lyso-lactosylceramide|N-Glycine 1-beta-lactosyl-sphing-4-enine

点击：N-糖化乳糖基鞘氨醇-N-Glycinated lactosylsphingosine查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询艾美捷科技有限公司。更多Matreya公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。

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