双唾液酸神经节苷脂GD3（NH4 +盐）|Disialoga

双唾液酸神经节苷脂GD3（NH4 +盐），Disialoganglioside GD3 (NH4+ salt)，Disialoganglioside GD3

产品名称：双唾液酸神经节苷脂GD3（NH4 +盐）-Disialoganglioside GD3 (NH4+ salt)

产品货号：1504-25

产品规格：25mg

背景资料：Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. GD3 is predominantly expressed during neuronal development and its expression becomes very limited in adult tissues. GD3 expression is unusually high in basal cell carcinomas and malignant melanomas and is thought to be a human melanoma-specific antigen. Although GD3 is not immunogenic it has been investigated as a tool for immunotargeting human melanoma cells.3 Over expression of GD3 has led to apoptosis by recruiting mitochondria to apoptotic pathways and suppressing NF-κB activation and subsequent κB-dependent gene induction.4 Increased levels of GD3 have also been found to be associated with proliferative diseases, such as atherosclerosis.

保存建议：双唾液酸神经节苷脂GD3（NH4 +盐）-Disialoganglioside GD3 (NH4+ salt)对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：GD3

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