Tryptanthrin,13220-57-0

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Tryptanthrin

CAS No. : 13220-57-0

MCE 国际站：Tryptanthrin

产品活性：Tryptanthrin 是一种吲哚喹唑啉，可以是产自靛蓝植物的生物碱。Tryptanthrin 是一种口服有效的细胞白三烯 (LT) 生物合成抑制剂。Tryptanthrin 具有抗癌活性。Tryptanthrin 可抑制 NOS1、COX-2、NF-κB 的表达水平，调节 IL-2、IL-10、TNF-α 的表达水平。

研究领域：GPCR/G Protein  |  Immunology/Inflammation  |  NF-κB  |  Apoptosis

作用靶点：Leukotriene Receptor  |  NO Synthase  |  NF-κB  |  COX  |  TNF Receptor  |  Interleukin Related

In Vitro: Tryptanthrin (0-60 μM; 24, 48 and 72 h) inhibits the proliferation and colony formation of MCF-7 cells.
Tryptanthrin (6.25-25 μM; 48 h; MCF-7 cells) reverses EMT-associated E-cadherin, MMP-2 and Snail.
Tryptanthrin (0-30 μM; 15 min; MCF-7 cells) reduces Leukotriene (LT)-formation in human neutrophils with an IC₅₀ value of 0.6 μM.

In Vivo: Tryptanthrin (25-100 mg/kg; i.g.; daily, for 13 d; Female Bal b/c mice with 4T1 xenograft) inhibits tumor growth and regulates IL-2, IL-6, IL-10, IL-12 and TNF-α levels in tumor-bearing mice.
Tryptanthrin (10 mg/kg; p.o.; male Wistar Han rats) inhibits LTB₄ formation in vivo.

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