Mollugin大叶茜草素,55481-88-4

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Mollugin

CAS No. : 55481-88-4

MCE 国际站：Mollugin

产品活性：Mollugin 是一种口服有效的 NF-κB 抑制剂。Mollugin 诱导 HepG2 细胞 S 期阻滞，增加细胞内活性氧 (ROS) 水平。Mollugin 诱导 HepG2 细胞 DNA 损伤，并增加 p-H2AX 的表达。Mollugin 通过抑制 TNF-α 诱导的 NF-κB 活化而具有抗癌作用。Mollugin 通过 p38-Smad 信号通路增强 BMP-2 (骨形态发生蛋白 2) 的成骨作用。

研究领域：NF-κB  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  Apoptosis  |  Protein Tyrosine Kinase/RTK

作用靶点：NF-κB  |  Reactive Oxygen Species  |  Apoptosis  |  VEGFR  |  c-Myc

In Vitro: Mollugin (0-80 μM, 24 h) inhibits the expression of an NF-κB reporter gene induced by TNF-α in a dose-dependent manner.
Mollugin (0-80 μM, 12 h) inhibits the proliferation of HeLa cells.
Mollugin (0-80 μM, 12 h) inhibits TNF-α-induced phosphorylation and nuclear translocation of p65, phosphorylation and degradation of IκBα, and IKK phosphorylation, and inhibits the TNF-α-induced mRNA expression of Cyclin D1, c-Myc, and VEGF.
Mollugin (0-80 μM, 12 h) enhances TNF-α-induced apoptosis.

In Vivo: Mollugin (0-75 mg/kg, Orally, three times per week for 36 days) inhibits growth of HeLa cells in a xenograft tumor model.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Protein Tyrosine Kinase Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Differentiation Inducing Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Terpenoids Library  |  Phenols Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  Glutamine Metabolism Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Angiogenesis-Related Compound Library  |  Mitochondria-Targeted Compound Library  |  Transcription Factor-Targeted Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Cancer Natural Product Library  |  Antidepressant Compound Library  |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  Human Metabolite Library  |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Osteogenesis Compound Library  |  Cancer Stem Cells Compound Library  |  Pain-Related Compound Library  |  Mitochondrial Protection Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Cytokine Inhibitors Library  |  Cell Death Library  |  MG-132  |  Phorbol 12-myristate 13-acetate  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  LY294002  |  Tamoxifen  |  Paclitaxel  |  Y-27632  |  Acetylcysteine  |  Angiotensin II human  |  2-Deoxy-D-glucose  |  Staurosporine  |  H2DCFDA  |  SB-431542  |  Actinomycin D  |  Deferoxamine mesylate  |  Bortezomib  |  5-Fluorouracil  |  Trametinib  |  Sorafenib  |  Oxaliplatin  |  Gemcitabine  |  Temozolomide  |  Rotenone  |  Mdivi-1  |  Elesclomol  |  Ruxolitinib  |  Decitabine  |  SP600125  |  MK-2206 dihydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds