- ￥600 - 1800
- MedChemExpress(MCE)
- 美国
- HY-12542A
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Dantrolene sodium hydrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
24868-20-0
- 规格：
10 mM * 1 mL/100 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥600.0 |
| 规格： | 500 mg | 产品价格： | ￥1800.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Dantrolene sodium hemiheptahydrate
CAS No. : 24868-20-0
MCE 国际站：Dantrolene sodium hemiheptahydrate
产品活性：Dantrolene sodium hemiheptahydrate 是一种具有口服活性的、非竞争性谷胱甘肽还原酶抑制剂，Ki 为 111.6 μM，IC50 为 52.3 μM。Dantrolene sodium hemiheptahydrate 是一种兰尼定受体 (RyR) 拮抗剂和 Ca2+ 信号稳定剂。Dantrolene sodium hemiheptahydrate 是一种直接作用的骨骼肌松弛剂。Dantrolene sodium hemiheptahydrate 可用于肌肉痉挛、恶性高热、亨廷顿病和其他抗精神病药恶性综合征的研究。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Autophagy
作用靶点：Calcium Channel | Autophagy
In Vitro: Dantrolene (60 μM; at 1 and 3 days) sodium hemiheptahydrate significantly inhibits ACTA2 expression and upregulats RUNX2 expression in paVICs.
Dantrolene (60 μM; overnight pretreatment) sodium hemiheptahydrate inhibits LPC-induced calcium flux in porcine aortic valve interstitial cells.
Dantrolene (10, 30, 60 μM) sodium hemiheptahydrate inhibits calcific nodule formation of paVICs due to 10 μM lysophosphatidylcholine (LPC).
In Vivo: Dantrolene (5 mg/kg; fed orally twice per week) sodium hemiheptahydrate improves performance in the beam-walking and gait-walking assay.
Dantrolene (10 mg/kg; IP; three days per week; for 40-60 days) sodium hemiheptahydrate significantly improves gait, reduces LC3-II levels, improves mitochondrial ATP production and reduced inflammation in the brain. Dantrolene sodium hemiheptahydrate partially reduces autophagy and the expression of CALM (calmodulin) in the brain of neuronopathic Gaucher disease mice.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | CNS-Penetrant Compound Library | Autophagy Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Neuroprotective Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Rare Diseases Drug Library | Calcium Channel Blocker Library | Human Metabolite Library | Off-patent Drug Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Cell Death Library | Ion Channel Compound Library | Thapsigargin | Ionomycin | L-Ascorbic acid | Minocycline hydrochloride | Verapamil | 2-Aminoethyl diphenylborinate | Acetylcholine chloride | GSK1016790A | Nifedipine | Fasudil Hydrochloride | Ebselen | Halofuginone | Tetrandrine | Carbamazepine | Ruthenium red | CDN1163 | ISX-9 | Gabapentin | TPC2-A1-N | Bay K 8644 | Ethacrynic acid | L-Phenylalanine | Istaroxime hydrochloride | Amlodipine | Digitoxin | Diltiazem hydrochloride | Cromolyn sodium
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验。 【不良反应】 1．心血管和呼吸系统 药物剂量超过外科麻醉量的2~4倍时，可明显抑制心脏和呼吸功能，甚至导致死亡。全麻时由于正常反射消失，胃内容物可返流并被吸入肺，引起支气管痉挛和术后肺炎。 2．恶性高热 此反应极为罕见，液体吸入麻醉药均可引起，与遗传有一定关系。表现为高热，体温可高达43℃，伴有心动过速、高血压、酸中毒和高血钾等，肌松药succinylcholine可诱发此反应。应用单曲林（dantrolene）、降体温、纠正电解质和酸碱
. Cytotoxic (metabolic): Toxins cause failure of the active transport mechanisms. Loss of intracellular potassium and influx of sodium (and water) cause cells in the brain to swell. Ischemic: Due to cerebral
技术资料暂无技术资料 索取技术资料
