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货期：1-2天
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MedChemExpress LLC
- CAS号：
1476-52-4
- 规格：
2500 μg
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Desethyl chloroquine
CAS No. : 1476-52-4
MCE 国际站：Desethyl chloroquine
产品活性：Desethyl chloroquine 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine 具有抗疟原虫活性。
研究领域：Anti-infection | Immunology/Inflammation | Autophagy
作用靶点：Parasite | Toll-like Receptor (TLR) | Autophagy
In Vitro: P. falciparum
In Vivo: Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.
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文献和实验Antibody-Bearing Liposomes as Chloroquine Vehicles in Treatment of Murine Malaria
because the malarial parasites are rapidly developing resistance to the existing antimalarial drugs, like chloroquine (2 ), when given in classical pharmaceutical forms. Studies on the molecular basis of chloroquine resistance suggest that enhanced active efflux
疟原虫 Malaria Parasites(Plasmodium)
symptomsEradication of gametocytesPrevent relapseMALARIA TREATMENTP. falciparum.This species was originally sensitive to chloroquine, however, strains resistant to this and other antimalarial drugs are now commonplace. Because the parasite is able to multiply
Vaccination Using Normal Live Sporozoites Under Drug Treatment
by irradiation or genetic manipulations. It has been demonstrated recently that immunization with normal sporozoites under chloroquine cover confers sterile protection in mice and humans, using substantially fewer parasites and injections than with irradiated
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