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- 文献和实验
- 技术资料
- 保存条件：
4°C, protect from light, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
247912-76-1
- 规格：
1 mg/5 mg/10 mg/25 mg
| 规格： | 1 mg | 产品价格： | ￥1818.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥4000.0 |
| 规格： | 10 mg | 产品价格： | ￥6000.0 |
| 规格： | 25 mg | 产品价格： | ￥8700.0 |
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Desethyl chloroquine diphosphate
CAS No. : 247912-76-1
MCE 国际站：Desethyl chloroquine diphosphate
产品活性：Desethyl chloroquine diphosphate 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine diphosphate 具有抗疟原虫活性。
研究领域：Anti-infection | Immunology/Inflammation | Autophagy
作用靶点：Parasite | Toll-like Receptor (TLR) | Autophagy
In Vivo: Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.
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文献和实验aliquots at -20°C) 2x HBS (Hepes buffered saline) 100 mM chloroquine (0.516g chloroquine diphosphate, 10 mL H2O, 0.2 µm filtered, store aliquots at -20°C) DMEM with 10% FBS and 1x penicillin-streptomycin Polybrene 1000x (4 mg/ mL
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