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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Desethylhydroxychloroquine oxalate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
14142-64-4
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥2800.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥7000.0 |
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Cletoquine oxalate
CAS No. : 14142-64-4
MCE 国际站：Cletoquine oxalate
产品活性：Cletoquine oxalate (Desethylhydroxychloroquine oxalate) 是 Hydroxychloroquine 的主要活性代谢产物，是由 CYP2D6，CYP3A4，CYP3A5 和 CYP2C8 同工酶在肝脏中形成的。Cletoquine oxalate 也是一种 Chloroquine 衍生物，具有抗基孔肯雅热病毒 (CHIKV) 的能力。Cletoquine oxalate 具有抗疟作用，并可用于自身免疫性疾病的研究。
研究领域：Anti-infection
作用靶点：Influenza Virus | Parasite
In Vivo: Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5).
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文献和实验The amounts of oxalate and citrate excreted in urine, and their urinary concentrations are important risk factors for the development of calcium oxalate kidney stones (1 ). The most widely used procedures to estimate these analytes
Oxalate is a common constituent of many plant species. Some crop plants accumulate high levels of this dicarboxylic acid anion (oxalate). Depending on the species, oxalate accumulates primarily as soluble oxalate, insoluble calcium oxalate
Cytochrome Oxidase Manometric Analysis
Materials 0.01 M Potassium Phosphate Buffer, pH 7.4 Sat. K Fe(CN) 0.6 M Sodium Malonate (Malonic acid, sodium salt) 5 mM KCN 0.02% (w/v) p-phenylenediamine oxalate (PPDO)
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