DHODH-IN-8,1148126-03-7

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DHODH-IN-8

CAS No. : 1148126-03-7

MCE 国际站：DHODH-IN-8

产品活性：DHODH-IN-8 (Compound 27) 是一种人和恶性疟原虫二氢乳清酸脱氢酶的抑制剂，IC₅₀ 分别为 0.13 μM 和 47.4 μM，K_i 分别为 0.016 μM 和 5.6 μM。DHODH-IN-8 具有抗疟疾能力。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease  |  Cell Cycle/DNA Damage

作用靶点：Parasite  |  Dihydroorotate Dehydrogenase  |  DNA/RNA Synthesis

In Vitro: The dihydroorotate dehydrogenases (DHODHs) are attractive chemotherapeutic targets in various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and for the treatment of human disease. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by utilizing an FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. The human DHODH (HsDHODH)a and the P. falciparum DHODH (PfDHODH) both belong to the group of class 2 DHODHs that use respiratory quinones as the terminal electron acceptors.

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