GP120 转基因小鼠

转基因“减肥”小鼠问世

10b基因连接到脂肪组织特异表达的FABP4启动子上，通过常规转基因技术获得转基因小鼠。在FABP4启动子调控下，转基因小鼠脂肪组织中Wnt10b表达比正常情况高50倍。Wnt10b基因在正常小鼠的白色和棕色两种脂肪组织内的作用不同，转基因小鼠只有正常白色脂肪的一半，而没有棕色脂肪，这使得它无法维持自身体温从而容易受到寒冷的攻击。研究人员无法解释这种转基因小鼠的皮肤比正常小鼠厚2倍，体重较重，耗氧量也较少，然而更奇怪的是它们活得都很健康。 脂肪组织负责产生机体响应胰岛素的leptin

Virion Attachment and Entry: HIV gp120 Env Biotinylation, gp120 Env, or Integrin Ligand-Binding Assay

The HIV-1 entry receptors are CD4 and a chemokine receptor (CCR5 or CXCR4). In addition it has recently been demonstrated that HIV-1 gp120 binds to and signals through integrin α4 β7 , the gut-homing receptor (Arthos et al., Nat Immunol

Inhibition of HIV Infection by Lectin Binding to gp120

Human immunodeficiency virus (HIV) is the causative agent of AIDS (acquired immunodeficiency syndrome). The polypeptide precursor gp160 of HIV-1 forms the external glycoprotein, gp120 and the transmembrane glycoprotein, gp41 (1 ). Sequence