Puromycin Dihydrochloride (嘌呤霉素)产品图
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Puromycin Dihydrochloride (嘌呤霉

素)
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  • ¥208 - 3298
  • 碧云天(beyotime)已认证
  • ST551
  • 2026年09月01日
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    • 规格:

      10mg/ml×1ml/10mg/ml×5ml/250mg

    规格:10mg/ml×1ml产品价格:¥208.0
    规格:10mg/ml×5ml产品价格:¥868.0
    规格:250mg产品价格:¥3298.0

    Puromycin是来源于Streptomyces alboniger的一种氨基核苷类抗生素,中文名为嘌呤霉素,常用于筛选通过质粒转染/转
    化、病毒感染等方法能表达pac基因(puror)的真核或原核多克隆或单克隆细胞。Puromycin不仅用于稳定细胞株的筛选,也用于稳定细胞株的维持。本产品的10mg/ml包装经过滤除菌,可以直接用于细胞培养。
          Puromycin的特点是快速作用于细胞,一般2天内可以杀死99%的不表达pac基因的细胞。
          在革兰氏阳性菌、动物或昆虫细胞中,嘌呤霉素通过抑制蛋白质合成而抑制或杀死细胞。其作用机制为嘌呤霉素是氨酰-tRNA分子3'末端的类似物,能够与核糖体的A位点结合并掺入到延伸的肽链中。嘌呤霉素与A位点结合后,不会参与随后的任何反应,从而导致蛋白质合成的提前终止并释放出C-末端含有嘌呤霉素的不成熟多肽。
          Pac基因表达嘌呤霉素N-乙酰转移酶(Puromycin N-acetyl-tranferase),该基因是在Streptomyces alboniger中发现的。如果表达基因,就会对嘌呤霉素产生抗性,这一特性目前普遍应用于筛选表达pac基因的哺乳动物稳定细胞株等。例如,很多商业化的慢病毒载体都携带pac基因(一般在质粒图谱上标记为puror),从而利用嘌呤霉素筛选特定基因的稳定表达细胞株。嘌呤霉素也可以用来筛选表达pac基因的大肠杆菌菌株、酵母菌株等。
          化学性质

    化学名 (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride 产品细节图片1
    化学式 C22H29N7O5•2HCl
    分子量 544.43
    CAS号 58-58-2
    纯度 >98%

          本产品10mg/ml包装配制在20mM HEPES(pH7.4)溶液中,浓度为10mg/ml,经0.22μm滤膜过滤除菌,可以直接用于细胞培养。本产品250mg包装为粉末装。
    包装清单:

    产品编号 产品名称 包装
    ST551-10mg Puromycin Dihydrochloride (嘌呤霉素) 10mg/ml×1ml
    ST551-50mg Puromycin Dihydrochloride (嘌呤霉素) 10mg/ml×5ml
    ST551-250mg Puromycin Dihydrochloride (嘌呤霉素) 250mg
    — 说明书 1份

    保存条件:
            -20℃保存,至少一年有效。10mg/ml包装避免反复冻融。
    注意事项:
           本产品对人体有害,操作时请小心,并注意有效防护以避免直接接触人体或吸入体内。
           本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
           为了您的安全和健康,请穿实验服并戴一次性手套操作。

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    图标文献和实验
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