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- P5984-2μg
- 2025年08月25日
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- 规格：
2μg
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| P5984-2μg | Recombinant Murine IL-36β, 183a.a. | 2μg | 646.00元 |
| P5984-10μg | Recombinant Murine IL-36β, 183a.a. | 10μg | 1613.00元 |
| P5984-100μg | Recombinant Murine IL-36β, 183a.a. | 100μg | 12333.00元 |
| P5984-1mg | Recombinant Murine IL-36β, 183a.a. | 1mg | 39452.00元 |
| Species | Gene ID | Accession | Source | Length | MW | Tag |
| Mouse | 69677 | Q9D6Z6 | E. coli | 183aa | 20.9kDa | － |
| About this Antibody | |
| Name | Recombinant Murine IL-36β, 183a.a. (Recombinant Murine Interleukin-36β, 183a.a.; rMuIL-36β, 183a.a.)；Recombinant Mouse IL-36β, 183a.a. ; 重组小鼠白细胞介素36β，183a.a. |
| Synonyms | FIL1 eta; IL-1 eta; IL1F8; IL-1H2; IL36B; family of interleukin 1-eta; FIL1; FIL1 eta; FIL1-(ETA); FIL1H; FILI-(ETA); IL-1 eta; IL1-ETA; IL1F8; IL-1F8; IL1F8 (Canonical product IL-1F8a); IL-1F8 (FIL1-eta); IL1H2; IL-1H2; interleukin 1 family, member 8 (eta); interleukin 1, eta; Interleukin 36, Beta; Interleukin-1 eta; interleukin-1 family member 8; Interleukin-1 homolog 2; Interleukin-1 Superfamily e; Interleukin-36 Beta |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active when compared to standard. The specific activity determined by its ability in a functional ELISA. Immobilized rMuIL-36β at 1μg/ml can bind recombinant murine IL-1 Rrp2 with a range of 0.15-5μg/ml. |
| Physical Appearance | Sterile Filtered lyophilized (freeze-dried) liquid-like powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated solution in 20mM Tris, 300mM NaCl, pH8.0, 5% trehalose. |
| Endotoxin | Less than 1EU/μg of rMuIL-36β, 183a.a. as determined by LAL method. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions. |
| Category | Cytokine |
| Background | Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases. IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36 beta is reported to be expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin and it can stimulate production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. It beta has two isoforms. IL-36β isoform 2 contains one potential N-linked glycosylation site in its C-terminus, while IL -36β isoform 1 lacks potential N-linked glycosylation sites and four of the conserved β-strands. Within the IL-1 family, IL-36β/IL-1F8 shares 30%, 32%, 37%, 46%, 34%, 45% and 28%a.a. sequence identity with IL-1 ra, IL-1β, IL-36Ra/IL-1F5, IL-36α/IL-1F6, IL-37/IL-1F7, IL-36γ/IL-1F9 and IL-1F10, respectively. |
| Amino Acid Sequence | MMAFPPQSCV HVLPPKSIQM WEPNHNTMHG SSQSPRNYRV HDSQQMVWVL TGNTLTAVPA SNNVKPVILS LIACRDTEFQ DVKKGNLVFL GIKNRNLCFC CVEMEGKPTL QLKEVDIMNL YKERKAQKAF LFYHGIEGST SVFQSVLYPG WFIATSSIER QTIILTHQRG KLVNTNFYIE SEK |
包装清单:
| 产品编号 | 产品名称 | 包装 |
| P5984-2μg | Recombinant Murine IL-36β, 183a.a. | 2μg |
| P5984-10μg | Recombinant Murine IL-36β, 183a.a. | 10μg |
| P5984-100μg | Recombinant Murine IL-36β, 183a.a. | 100μg |
| P5984-1mg | Recombinant Murine IL-36β, 183a.a. | 1mg |
| - | 说明书 | 1份 |
保存条件:
-20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以首次配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品在冻干时添加了海藻糖作为保护剂，此时冻干后本产品看起来仍然像是液体，属于正常现象。在冻干工艺上，海藻糖作为常用的冻干保护剂，可显著阻止蛋白质二级结构的改变，防止冻干过程中的蛋白变性。
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