- ￥3031.94
- nsjbio
- V2474-20UG
- 2025年07月15日
- Mouse
- Human. Other species not tested.
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Human umbilical vein endothelial cells (HUVEC) were used as the immunogen for the CD55 antibody.
- 亚型：
Mouse IgG1, kappa
- 克隆性：
单克隆
- 适应物种：
Human. Other species not tested.
- 宿主：
Mouse
- 规格：
20 ug
Primary antibody
纯化方法：
Purified
通用信息：
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
产品描述：
Recognizes a single chain glycoprotein of 70kDa, identified as CD55 (also known as decay accelerating factor, DAF). This mAb was clustered in Kobe at the Sixth International Workshop on Human Leukocyte Differentiation Antigens as F429D-9 (N-L120). CD55/DAF is widely expressed on cells throughout the body including leukocytes, erythrocytes, epithelium, endothelium, and fibroblasts. It is a Glycosyl phosphatidylinositol anchored (GPI-anchored) member of the membrane bound complement regulatory proteins that inhibit autologous complement cascade activation. It prevents the amplification steps of the complement cascade by interfering with the assembly of the C3-convertases, C4b2a and C3bBb, and the C5-convertase, C4b2a3b and C3bBb3b. CD55 also serves as receptor for CD97 and for echovirus and Coxsackie B virus. Anti-CD55 can be used as marker for paroxysmal nocturnal hemoglobinuria (PNH).
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文献和实验CD55 分子 CD55 常用单克隆抗体或代号： 143- 30,BRIC110,BRIC123;(DAF) 主要表达细胞： 广泛 [NL] 分子质量(kDa)和结构： gp70(GPI连接) 功 能： 衰变加速因子,调节补体活化 CD55 Aka decay accelerating factor Binds C3bBb (alternative pathway
网络 三、促衰变因子（CD55） 促衰变因子（decay accelerating factor,DAF）是Nicholson-Weller等（1981）用正丁醇提取后，再以层析法从人和豚鼠红细胞基质中纯化的一种膜蛋白。因其具有促进C3转化酶衷变的活性故名。经在还原条件下做SDS-PAGE并以过碘酸
of complement, DAF (decay accelerating factor or CD55) and MIRL (membrane inhibitor of reactive lysis or CD59). DAF and MIRL are cell-surface proteins that function as inhibitors of complement-mediated cell lysis, but act at different stages
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