CD55分子
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CD55 分子
CD55
常用单克隆抗体或代号： 143- 30,BRIC110,BRIC123;(DAF)
主要表达细胞： 广泛 [NL]
分子质量(kDa)和结构： gp70(GPI连接)
功 能： 衰变加速因子,调节补体活化
CD55
Aka decay accelerating factor
Binds C3bBb (alternative pathway convertase) and C4b2a (classical pathway convertase) to accelerate decay of the C3 convertases; protects against inappropriate complement activation
Receptor for CD97
Receptor for echovirus and Coxsackie B virus
Deficient in red blood cells from patients with paroxysmal nocturnal hemoglobinuria
Positive staining (normal): all hemaoietic cells and all cell types in intimate contact with complement proteins; also epithelial cells lining extracellular compartments, body fluids, extracellular matrix
