- $1280
- sciencell
- SP3D-3200
- 美国
- 2025年12月04日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
咨询销售
- 英文名：
SP3D-HPAEpiS
- CAS号：
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- 保质期：
见产品
- 供应商：
sciencell
- 保存条件：
液氮保存
Ready-to-use 3D Human Pulmonary Alveolar Epithelial Cell Spheroids：
The lung is a complex organ with a large and highly vascularized epithelial surface area. Gas exchange in the lung occurs in the air-filled alveoli containing type I and II alveolar epithelial cells. Type II cells function as progenitor cells in the alveoli and proliferate and differentiate into type I cells, while type I cells are involved in gas exchange [1]. Type II cells not only proliferate to maintain the epithelium but also play critical roles in respiration and host defense mechanism through production of the pulmonary surfactants (SPs) [1]. Type II cells, however, lose their functional markers within a few days of cultivation in 2D culture. Studies have shown that when alveolar epithelial cells are cultured in three-dimensional (3D) cell culture, cells maintain their epithelial functional markers [2]. To provide a more native in vitro lung model, ScienCell offers ready-to-use human pulmonary alveolar epithelial cell spheroids (SP3D-HPAEpiS), which express the surfactant proteins such as SP-A, -B, -C, and –D (Figures 1 and 2). These spheroids are ready for experiments at 24 hours post thawing, and are an excellent in vitro model for studying the contribution of the alveolar epithelial cells to alveolar maintenance and repair.肺是一个复杂的器官，具有大而高度血管化的上皮表面积。肺内气体交换发生在含有I型和II型肺泡上皮细胞的充气肺泡内。II型细胞在肺泡中起祖细胞的作用，增殖分化为I型细胞，I型细胞参与气体交换[1]。II型细胞不仅通过增殖维持上皮细胞，还通过产生肺表面活性剂(SPs)[1]在呼吸和宿主防御机制中发挥重要作用。然而，在2D培养的几天内，II型细胞失去了它们的功能标记。研究表明，肺泡上皮细胞在三维(3D)细胞培养中，细胞维持其上皮功能标志物[2]。提供更多本机体外肺模型,ScienCell提供现成的人类肺肺泡上皮细胞球状体(SP3D-HPAEpiS),蛋白质表达的表面活性剂如SP-A - b, c,和- d(图1和图2)。这些球状体准备好实验在解冻后24小时,和一个优秀的体外模型研究的贡献肺泡上皮细胞,肺泡进行维护和维修。
| Catalog No. | SP3D-3200 |
|---|---|
| Country of Manufacture | United States |
| Product Code | SP3D-HPAEpiS |
| Size/Quantity | |
| Product Use | SP3D-HPAEpiS are for research use only. It is not approved for human or animal use, or application in clinical or in vitro diagnostic procedures. |
| Storage | |
| Shipping Info | SP-3200, 3D-4152, 0004, 0583 are shipped on dry ice. 3D-3201, and (0343 or 0353 or 0383) are shipped at room temperature. |
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文献和实验Pulmonary Epithelial Cell Culture
of the peripheral gas exchange (pulmonary) region of the lung. The pulmonary epithelium is composed of alveolar type I and type II epithelial cells, which are present in a 1:2 ratio. Alveolar type II cells differentiate into type I cells as part of the normal
Isolation, Cultivation, and Application of Human Alveolar Epithelial Cells
of representative in vitro models. Thereby, human alveolar epithelial cells (hAEpC) are a suitable test system allowing standardized toxicity and transport studies for newly developed compounds and delivery systems. The isolation, purification, and cultivation
Isolation and Culture of Human Alveolar Epithelial Cells
will concentrate on the isolation and culture of human alveolar epithelial cells that line the peripheral gas exchange region of the lung. Whereas immortalized cell lines emanating mostly from the different cells of the tracheal/bronchial epithelium of human
