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文献和实验NLRP3 Inflammasome Activation and Cytotoxicity Induced by Particulate Adjuvants
particle-induced cytotoxicity. More specifically, protocols are described for the preparation and differentiation of BMDCs, their priming and stimulation using particulate NLRP3 agonists such as monosodium urate monohydrate (MSU) and the vaccine adjuvant
In Vivo Evaluation of Neutrophil Recruitment in Response to Sterile Particulates
Sterile particulates such as monosodium urate crystals induce inflammasome activation resulting in activation of caspase-1, secretion of IL-1α, and processing of IL-1β. Local production and activation of IL-1 leads to neutrophil recruitment
Experimentally Induced Rodent Models of Type 2 Diabetes
where rodents are the best choice of use due to being smaller in size, easy to handle, omnivorous in nature, and non-wild tranquil behavior. Normally rodent models are classified into two major classes namely: (1) genetic or spontaneously induced models
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