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- Adipogen
- 瑞士
- AG-CN2-0105-M001
- 2026年03月02日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 英文名：
Prodigiosin
- CAS号：
82-89-3
- 保质期：
Stable for at least 3 years after receipt when stored at -20°C.
- 保存条件：
-20°C
- 库存：
少量现货
- 供应商：
欣博盛生物
- 规格：
1 mg/250 ug
| 规格： | 1 mg | 产品价格： | ￥2700.0 |
|---|---|---|---|
| 规格： | 250 ug | 产品价格： | ￥900.0 |
Prodigiosin产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-CN2-0105-M001，包装规格是1 mg。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
Description
Red-pigmented antibiotic [1].
Antimalarial [2, 13].
Immunosuppressive [3, 7, 11, 12].
Apoptosis inducer [4-6, 15].
Cytotoxic. Induces phosphorylation of p38-MAPK [8].
Antimetastatic. Tumor invasion inhibitor [9].
Induces p21WAF1/CIP1 expression [10].
Anticancer compound [11, 12, 15].
gp91(phox) and iNOS expression inhibitor [14].
mTORC1 and mTORC2 complex inhibitor [16].
Down-regulates SKP2 to induce p27(KIP1) stabilization [17].
Blocking autophagosome-lysosome fusion [19].
Synonyms NSC 47147; BRN 4526727
Product Type Chemical
Properties
Formula
C20H25N3O
MW 323.4
Merck Index 14: 7767
CAS 82-89-3
Source/Host Chemicals Isolated from γ-proteobacterium strain MS-02-063.
Purity Chemicals ≥95% (HPLC)
Appearance Dark red solid.
Solubility Soluble in methanol, ethanol, chloroform, ethyl acetate, hexane, ace-tone or acetonitrile. Insoluble in water.
InChi Key SZXDNGVQRDTJSD-FOWTUZBSSA-N
Smiles CCCCCC1=C\C(=C/C2=C(OC)C=C(N2)C2=CC=CN2)N=C1C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
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- 作者
- 内容
- 询问日期
文献和实验- The Antibiotic Activity of Violacein, Prodigiosin, and Phthiocol: H.C. Lichstein & V.F. Van De Sand; J. Bacteriol. 52, 145 (1946)
- Antimalarial activity of prodigiosin: A.J. Castro; Nature 213, 903 (1967)
- T-cell specific immunosuppression by prodigiosin isolated from Serratia marcescens: S.B. Han, et al.; Int. J. Immunopharmacol. 20, 1 (1998)
- Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines: B. Montaner, et al.; Br. J. Pharmacol. 131, 585 (2000)
- Prodigiosin-induced apoptosis in human colon cancer cells: B. Montaner & R. Perez-Tomas; Life Sci. 68, 2025 (2001)
- Prodigiosin induces cell death and morphological changes indicative of apoptosis in gastric cancer cell line HGT-1: C. Diaz-Ruiz, et al.; Histol. Histopathol. 16, 415 (2001)
- Prodigiosin blocks T cell activation by inhibiting interleukin-2Ralpha expression and delays progression of autoimmune diabetes and collagen-induced arthritis: S.B. Han, et al.; JPET 299, 415 (2001)
- The cytotoxic prodigiosin induces phosphorylation of p38-MAPK but not of SAPK/JNK: B. Montaner & R. Perez-Tomas; Toxicol. Lett. 129, 93 (2002)
- Antimetastatic effect of prodigiosin through inhibition of tumor invasion: J. Zhang, et al.; Biochem. Pharmacol. 69, 407 (2005)
- The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factor-beta receptor pathway: V. Soto-Cerrato, et al.; Biochem. Pharmacol. 74, 1340 (2007)
- Prodigiosins as anti cancer agents: living upto their name: R. Pandey, et al.; Curr. Pharm. Des. 15, 732 (2009)
- New insights on the antitumoral properties of prodiginines: R. Perez-Tomas & M. Vinas; Curr. Med. Chem. 17, 2222 (2010)
- Prodigiosin produced by Serratia marcescens NMCC46 as a mosquito larvicidal agent against Aedes aegypti and Anopheles stephensi: C.D. Patil, et al.; Parasitol. Res. 109, 1179 (2011)
- Prodigiosin inhibits gp91(phox) and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia-ischemia: C.C. Chang, et al.; Toxicol. Appl. Pharmacol. 257, 137 (2011)
- Prodigiosin, the red pigment of Serratia marcescens, shows cytotoxic effects and apoptosis induction in HT-29 and T47D cancer cell lines: D. Dalili, et al; Nat. Prod. Res. 26, 2078 (2011)
- Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: prodigiosin vs. obatoclax: M. Espona-Fiedler, et al.; Biochem. Pharmacol. 83, 489 (2012)
- Prodigiosin down-regulates SKP2 to induce p27(KIP1) stabilization and antiproliferation in human lung adenocarcinoma cells: H.Y. Hsieh, et al.; Br. J. Pharmacol. 166, 2095 (2012)
- Sensitivity of Bacillus oleronius, a bacterium that is associated with rosacea, to prodigiosin: M.V. Sayger, et al.; Science Matters (2020)
- Prodigiosin impairs autophagosome-lysosome fusion that sensitizes colorectal cancer cells to 5-fluorouracil-induced cell death: C. Zhao, et al.; Cancer Lett. 481, 15 (2020)
粘质沙雷氏菌（ Serratia marce-scens）产生的红色色素。不溶于水，可溶于氯仿和乙醚。这种细菌在受潮的面包上繁殖，即产生此色素，故使面包成为血红般的颜色。因而中世纪的人们把出现这种“圣餐式”的面包现象，看作是基督的显身。
亦称灵菌。一种产生鲜红色素的细菌。存在于空气和水中，可生长在动、植物性食品中。通常为0.7微米左右的近球形短杆菌，但形态多样。革兰氏阴性，有周生鞭毛。厌氧条件下也可以生长，但不产生色素。色素为灵菌红素（ prodigiosin），其生理作用不明。按 Bergey氏分类法，属于肠道细菌类。
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