- ￥4800
- Adipogen
- AG-25B-0006-C100
- 瑞士
- 2025年07月14日
- Flow Cytometry (1:1000; Reference 22) Immunocytochemistry (1:200) Immunohistochemistry: (1:500; paraffin sections) Immunoprecipitation: (1:200) Western Blot: (1:1000) Functional Application: (see Protocol, preservative-free version AG-25B-0006PF available)
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体名：
anti-Asc
- 抗体英文名：
anti-Asc
- 浓度：
1mg/ml
- 应用范围：
Flow Cytometry (1:1000; Reference 22) Immunocytochemistry (1:200) Immunohistochemistry: (1:500; paraffin sections) Immunoprecipitation: (1:200) Western Blot: (1:1000) Functional Application: (see Protocol, preservative-free version AG-25B-0006PF available)
- 供应商：
欣博盛生物
- 库存：
99
- 级别：
科研
- 克隆性：
多克隆
- 保存条件：
-20°C
- 规格：
100 ug
anti-Asc, pAb (AL177)产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-25B-0006-C100，包装规格是100 ug。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
Asc promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. It is a component of the inflammasome, a protein complex which also includes NLRP3/NALP3, CARD8 and CASP1 and whose function is the activation of proinflammatory caspases.
Product Details
Synonyms Pycard; Target of Methylation-induced Silencing 1; TMS1; Caspase Recruitment Domain-containing Protein 5; Apoptosis-associated Speck-like Protein Containing CARD; CARD5
Product Type Polyclonal Antibody
Properties
Source/Host Rabbit
Immunogen/Antigen Synthetic peptide corresponding to aa at the N-terminal human Asc.
Application
Flow Cytometry (1:1000; Reference 22)
Immunocytochemistry (1:200)
Immunohistochemistry: (1:500; paraffin sections)
Immunoprecipitation: (1:200)
Western Blot: (1:1000)
Functional Application: (see Protocol, preservative-free version AG-25B-0006PF available)
The antibody AL177 can be used to measure inflammasome activation in vivo, detecting Asc speck formation by immunofluorescence and by Flow Cytometry.
Crossreactivity Human
Mouse
Specificity
Recognizes human and mouse Asc.
Purity Detail Epitope-affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 0.02% sodium azide.
Isotype Negative Control
Rabbit IgG Isotype Control
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
- 作者
- 内容
- 询问日期
文献和实验- NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini, et al.; Immunity 20, 319 (2004)
- P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1beta in Mouse Macrophage: P. Pelegrin, et al.; J. Immunol. 180, 7147 (2008)
- Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF: L. Kolly, et al.; J. Immunol. 183, 4003 (2009) [IF]
- Activation of autophagy by inflammatory signals limits IL-1b production by targeting ubiquitinated inflammasomes for destruction: C.-S. Shi, et al.; Nat. Immunol. 13, 255 (2012)
- NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice: M.T. Heneka, et al.; Nature 493, 674 (2013) [IF]
- Measuring inflammasome activation in response to bacterial infection: P. Broz & D.M. Monack; Methods Mol. Biol. 1040, 65 (2013)
- Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation: J.K. Dowling, et al.; J. Biol. Chem. 289, 6429 (2014)
- Localization and functionality of the inflammasome in neutrophils: M. Bakele, et al.; J. Biol. Chem. 289, 5320 (2014)
- The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation: B.S. Franklin, et al.; Nat. Immunol. 15, 727 (2014) [IF]
- The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response: A. Baroja-Mazo, et al.; Nat. Immunol. 15, 738 (2014)
- Aging-associated TNF production primes inflammasome activation and Nlrp3-related metabolic disturbances: F. Bauernfeind, et al.; J. Immunol. 197, 2900 (2016)
- Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence: M. Beilharz, et al.; Methods Mol. Biol. 1417, 145 (2016)
- Cell-Free Assay for Inflammasome Activation: Y. Jamilloux & F. Martinon; Methods Mol. Biol. 1417, 207 (2016)
- The inflammasome pathway in stable COPD and acute exacerbations: R. Faner, et al.; ERJ Open Res. 2, 00002-2016 (2016) [IF]
- A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly: F.I. Schmidt, et al.; J. Exp. Med. 213, 771 (2016) [IF]
- Detection of ASC Oligomerization by Western Blotting: J. Lugrin & F. Martinon; Bio Protoc. 7, e2292 (2017) (Protocol)
- Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease: C. Venegas, et al.; Nature 552, 355 (2017) [IF]
- The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer: E. Brunetto, et al.; J. Immunother. Cancer 7, 45 (2019) [IF]
- NLRP3 inflammasome activation drives tau pathology: C. Ising, et al.; Nature 575, 669 (2019) [IF]
- Human NLRP1 is a sensor for double-stranded RNA: S. Bauernfried, et al.; Science 371, 482 (2021)
- DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response: S. Kesavardhana, et al.; J. Biol. Chem. 296, 100579 (2021)
- Instructions for Flow Cytometric Detection of ASC Specks as a Readout of Inflammasome Activation in Human Blood: N. Wittmann, et al.; Cells 10, 2880 (2021) [Flow Cytometry]
- Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling: H. Xian, et al.; Immunity 55, 1370 (2022)
技术资料暂无技术资料 索取技术资料
