- ￥4800
- Adipogen
- AG-20B-0048-C100
- 瑞士
- 2026年02月28日
- WB
- Purified from concentrated hybridoma tissue culture supernatant.
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
anti-Caspase-1 (p20) (human), mAb (Bally-1)
- 抗体英文名：
anti-Caspase-1 (p20) (human), mAb (Bally-1)
- 浓度：
1mg/ml
- 应用范围：
WB
- 宿主：
Purified from concentrated hybridoma tissue culture supernatant.
- 供应商：
欣博盛生物
- 库存：
99
- 级别：
科研用
- 目录编号：
AG-20B-0048-C100
- 保质期：
见包装说明
- 克隆性：
单克隆
- 保存条件：
4°C
- 形态：
liquid
- 免疫原：
Recombinant human caspase-1.
- 规格：
100 ug
anti-Caspase-1 (p20) (human), mAb (Bally-1)产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-20B-0048-C100，包装规格是100 ug。
如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
caspase -1是最常用的炎性半胱天冬酶。它处理细胞因子白细胞介素-1β (IL-1β)和IL-18，诱导细胞自然死亡。Caspase-1被称为炎性小体的多蛋白复合物激活，以响应通过不同的炎性小体检测到的众多刺激。NLRC4对胞质鞭毛蛋白有反应，小鼠NLRP1b对炭疽致死毒素有反应，AIM2对胞质DNA有反应，NLRP3对包括晶体在内的各种激动剂有反应。
Description
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1β (IL-1β) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
More Information
Product Details
Synonyms Interleukin-1 β Convertase; IL-1BC; Interleukin-1 β-converting Enzyme; ICE
Product Type Monoclonal Antibody
Properties
Clone Bally-1
Isotype Mouse IgG1
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Recombinant human caspase-1.
Application
Western Blot (see online protocol): (1μg/ml)
Note: Depending on the used cell line we recommend to optimize the dilution.
Crossreactivity Human
Specificity
Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.
Purity ≥95% (SDS-PAGE)
Purity Detail Protein G-affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Isotype Negative Control
Mouse IgG1 Isotype Control
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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文献和实验- Measuring the inflammasome: O. Gross; Methods Mol. Biol. 844, 199 (2012)
- Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells: V. Derangere, et al.; Cell Death Differ. 21, 1914 (2014)
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signaling: N. Kayagaki, et al.; Nature 526, 666 (2015)
- Human monocytes engage an alternative inflammasome pathway: M.M. Gaidt, et al.; Immunity 44, 833 (2016)
- Cell-Free Assay for Inflammasome Activation: Y. Jamilloux & F. Martinon; Methods Mol. Biol. 1417, 207 (2016)
- The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner: M. Heulot, et al.; Oncotarget 7, 6342 (2016)
- Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation: F. Awad, et al.; PLoS ONE 12, e0175336 (2017)
- The DNA inflammasome in human myeloid cells is initiated by a STING-cell death program upstream of NLRP3: M.M. Gaidt, et al.; Cell 171, 1110 (2017)
- Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release: Y. Dautova, et al.; J. Mol. Cell Cardiol. 115, 82 (2017)
- POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity: L. Zhang, et al.; Nat. Commun. 9, 4225 (2018)
- SUMO-mediated regulation of NLRP3 modulates inflammasome activity: R. Barry, et al.; Nat. Commun. 9, 3001 (2018)
- The Crohn’s disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy: S. Mehto, et al.; Mol. Cell 73, 429 (2019)
- Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis: D. Fisch, et al.; EMBO J. 38, e100926 (2019)
- HSP70 is a negative regulator of NLRP3 inflammasome activation: P. Martine, et al.; Cell Death Diff. 10, 256 (2019)
- Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis: C. Wu, et al.; Immunity 50, 1401 (2019)
- SERPINB1-mediated checkpoint of inflammatory caspase activation: Y.J. Choi, et al.; Nat. Immunol. 20, 276 (2019) [Knock Down Validation]
- NLRP3 inflammasome activation drives tau pathology: C. Ising, et al.; Nature 575, 669 (2019)
- Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death: D. Fisch, et al.; Cell Rep. 32, 108008 (2020)
- Molecularly Distinct NLRP3 Inducers Mediate Diverse Ratios of Interleukin-1β and Interleukin-18 from Human Monocytes: K. Midtbo, et al.; Med. Inflamm. ID4651090 (2020)
- Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation: T. Douglas & M. Saleh; J. Biol. Chem. 295, 5216 (2020)
- AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner: S. Shah, et al.; Front. Cell Dev. Biol. 9, 588278 (2021)
- Human NLRP1 is a sensor for double-stranded RNA: S. Bauernfried, et al.; Science 371, 482 (2021)
- Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade: S. Roth, et al.; Immunity 54, 648 (2021)
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