- ￥4560
- Adipogen
- AG-20B-0042-C100
- 瑞士
- 2025年07月15日
- Western Blot；Immunocytochemistry；Immunoprecipitation
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体名：
anti-Caspase-1 (p20) (mouse), mAb
- 抗体英文名：
anti-Caspase-1 (p20) (mouse), mAb
- 浓度：
1mg/ml
- 应用范围：
Western Blot；Immunocytochemistry；Immunoprecipitation
- 供应商：
欣博盛生物
- 库存：
99
- 级别：
科研
- 克隆性：
单克隆
- 免疫原：
重组 mouse caspase-1
- 规格：
100 ug
anti-Caspase-1 (p20) (mouse), mAb (Casper-1)产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-20B-0042-C100，包装规格是100 ug。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
Anti-Caspase-1 (p20) (mouse)产品介绍
品牌：Adipogen
货号：AG-20B-0042-C100
品名：anti-Caspase-1 (p20) (mouse), mAb (Casper-1)
产品信息：
产品类型：单克隆抗体
克隆号：Casper-1
亚型：Mouse IgG1
来源：从浓缩杂交瘤组织培养上清中纯化。
免疫原：重组 mouse caspase-1.
应用：Western Blot；Immunocytochemistry；Immunoprecipitation
种属反应：Mouse
特异性：识别内源性全长和激活的(p20片段)小鼠caspase-1。
纯度：≥95% (SDS-PAGE)
纯化方式：G-affinity纯化的蛋白质。
浓度：1mg/ml
成分：液体. PBS中含有10%甘油和0.02%叠-氮-化-Na
阴性对照：Mouse IgG2b Isotype Control
产品介绍：
caspase -1是最常用的炎性蛋白酶。它用于处理细胞因子白细胞介素-1β (IL-1β)和IL-18，诱导细胞自然死亡。Caspase-1是炎性小体的多蛋白复合物激活物，以响应不同的炎性小体受到的众多刺激。NLRC4对胞质鞭毛蛋白有反应，小鼠NLRP1b对炭疽致死毒素有反应，AIM2对胞质DNA有反应，NLRP3对包括晶体在内的各种激动剂有反应。
更多详情请咨询Adipogen中国授权代理商深圳欣博盛生物技术公司。
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- 作者
- 内容
- 询问日期
文献和实验- Measuring the inflammasome: O. Gross; Methods Mol. Biol. 844, 199 (2012)
- Inflammasome Activators Induce Interleukin-1alpha Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1: O. Gross, et al.; Immunity 36, 388 (2012)
- Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation: Y. Yan, et al.; Immunity 38, 1154 (2013)
- LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition: J. Jin, et al.; Nat. Commun. 4, 2075 (2013)
- iGLuc: a luciferase-based inflammasome and protease activity reporter: E. Bartok, et al.; Nat. Methods 10, 147 (2013)
- Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection: C. Lupfer, et al.; Nat. Immunol. 14, 480 (2013)
- Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease: J.L. McAuley, et al.; PLoS Pathog. 9, e1003392 (2013)
- Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop: C. Juruj, et al.; Front. Cell. Infect. Microbiol. 3, 14 (2013)
- Inflammasome Activation by Altered Proteostasis: J.N. Shin, et al.; J. Biol. Chem. 288, 35886 (2013)
- Immunoblotting for active caspase-1: C. Jakobs, et al.; Methods Mol. Biol. 1040, 103 (2013)
- Inflammasome activation and inhibition in primary murine bone marrow-derived cells, and assays for IL-1α, IL-1β, and caspase-1: K.s. Schneider, et al.; Methods Mol. Biol. 1040, 117 (2013)
- FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes: P. Gurung, et al.; J. Immunol. 192, 1835 (2014)
- Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection: Md. H. Zaki, et al.; PNAS 111, 385 (2014)
- XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation: M. Yabal, et al.; Cell Rep. 7, 1796 (2014)
- The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation: B.S. Franklin, et al.; Nat. Immunol. 15, 727 (2014)
- The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response: A. Baroja-Mazo, et al.; Nat. Immunol. 15, 738 (2014)
- Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation: F. Madouri, et al.; J. Mol. Cell Biol. 7, 351 (2015)
- ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways: T. Kuriakose, et al.; Sci. Immunol. 1, aag2045 (2016)
- Assessing Caspase-1 Activation: B. Guey & V. Petrilli; Methods Mol. Biol. 1417, 197 (2016)
- IL-1beta and caspase-1 drive autoinflammatory disease independently of IL-1alpha or caspase-8 in a mouse model of familial mediterranean fever: D. Sharma, et al.; Am. J. Pathol. 187, 236 (2017)
- The DNA inflammasome in human myeloid cells is initiated by a STING-cell death program upstream of NLRP3: M.M. Gaidt, et al.; Cell 171, 1110 (2017)
- Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome: M.C. Okondo, et al.; Cell Chem. Biol. 25, 1 (2018)
- Complement Mediated Activation of the NLRP3 Inflammasome and its Inhibition by AAV Mediated Delivery of CD59 in a Model of Uveitis: B. Kumar, et al.; Mol. Ther. 26, 1568 (2018)
- IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation: R. Karki, et al.; Cell 173, 1 (2018)
- Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity: D. Boucher, et al.; J. Exp. Med. 215, 827 (2018)
- N-terminal degradation activates the NLRP1B inflammasome: A.J. Chui, et al.; Science 364, 82 (2019)
- Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes: Science 364, eaau1330 (2019)
- NLRP3 inflammasome activation drives tau pathology: C. Ising, et al.; Nature 575, 669 (2019)
- Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense: M. Zheng, et al.; Cell 181, 674 (2020)
- Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop: F. Chen, et al.; Bone Res. 8, 10 (2020) (Rat Samples)
- STING regulates metabolic reprogramming in macrophages via HIF-1α during Bru-cella infection: M.T.R. Gomes, et al.; PLoS Pathog 17, e1009597 (2021)
- DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response: S. Kesavardhana, et al.; J. Biol. Chem. 296, 100579 (2021)
- Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade: S. Roth, et al.; Immunity 54, 648 (2021)
- Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress: S. Zhang, et al.; Nature Transl. Psychiatry 12, 245 (2022) (Rat Samples)
- Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling: H. Xian, et al.; Immunity 55, 1370 (2022)
- ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection: R. Karki, et al.; Sci. Immunol. 7, eabo6294 (2022)
T-Cell Activation Using mAb to CD3
splenic T-cells and human peripheral T cells stimulated via CD3. Critical parameters include cell density, antibody titer and activation kinetics. Materials 1X sterile PBS Anti-mouse CD3e, Clone 145-2C11 (Functional Grade, Cat. No. 16
Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
Immunohistochemistry using Anti-Ganglioside Antibodies
supernatant containing antiganglioside mAb overnight at 4°C. The time of incubation may range from 30 min. to overnight as determined by experience. 5. Wash with 1% BSA in PBS 4 times. 6. Incubate in FITC-conjugated goat anti-mouse IgM F(ab
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