- ￥4800
- Adipogen
- AG-20B-0044-C100
- 瑞士
- 2026年03月02日
- WB
- Purified from concentrated hybridoma tissue culture supernatant.
- Mouse
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体名：
anti-Caspase-1 (p10) (mouse), mAb (Casper-2)
- 抗体英文名：
anti-Caspase-1 (p10) (mouse), mAb (Casper-2)
- 浓度：
1mg/ml
- 应用范围：
WB
- 宿主：
Purified from concentrated hybridoma tissue culture supernatant.
- 供应商：
欣博盛生物
- 库存：
99
- 级别：
科研用
- 目录编号：
AG-20B-0044-C100
- 保质期：
Stable for at least 1 year after receipt when stored at -20°C.
- 适应物种：
Mouse
- 保存条件：
-20°C
- 形态：
liquid
- 规格：
100 ug
anti-Caspase-1 (p10) (mouse), mAb (Casper-2)产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-20B-0044-C100，包装规格是100 ug。
如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
Description
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1β (IL-1β) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
Product Details
Synonyms Interleukin-1β Convertase; IL-1BC; Interleukin-1β-converting Enzyme; ICE
Product Type Monoclonal Antibody
Properties
Clone Casper-2
Isotype Mouse IgG2a
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Recombinant mouse caspase-1.
Application
Western Blot (see online protocol): (1μg/ml) (no need to precipitate the cell supernatant for the detection of caspase-1 (mouse) upon inflammasome activation)
Crossreactivity Mouse
Specificity
Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1.
Purity ≥95% (SDS-PAGE)
Purity Detail Protein G-affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Isotype Negative Control
Mouse IgG2a Isotype Control
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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- 作者
- 内容
- 询问日期
文献和实验Measuring the inflammasome: O. Gross; Methods Mol. Biol. 844, 199 (2012)
XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation: M. Yabal, et al.; Cell Rep. 7, 1796 (2014)
AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages: Y. Wang, et al.; Ann. Rheum. Dis. 75, 286 (2016)
Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome: C. Guo, et al.; Immunity 45, 802 (2016)
IL-18 is critical for MAIT cell IFN- responses to Francisella 1 species in vitro but not in vivo: E. Jesteadt, et al.; Infect. Immun. 86, e00117 (2018)
Interleukin-18 Is Critical for Mucosa-Associated Invariant T Cell Gamma Interferon Responses to Francisella Species In Vitro but Not In Vivo: E. Jesteadt, et al.; Infect. Immun. 86, e00117 (2018)
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity: D. Boucher, et al.; J. Exp. Med. 215, 827 (2018)
Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages: Ch. Guo, et al.; Immunity 49, 842 (2018)
Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome: WT. Wong, et al.; Front. Immunol. 9, 1920 (2018)
HSP70 is a negative regulator of NLRP3 inflammasome activation: P. Martine, et al.; Cell Death Diff. 10, 256 (2019)
Critical Role for the NLRP3 Inflammasome in Mediating IL-1β Production in Shigella sonnei-Infected Macrophages: LH. Li, et al. Front. Immunol. 11, 1115 (2020)
Mechanism of miR-126 in hypoxia-reoxygenationinduced cardiomyocyte pyroptosis by regulating HMGB1 and NLRP3 inflammasome: L. Fei, et al.; Immunopharmacol. Immunotoxicol. 44, 500 (2022)
CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout: S. Devi, et al.; Cell Rep. 42, 112265 (2023)
T-Cell Activation Using mAb to CD3
splenic T-cells and human peripheral T cells stimulated via CD3. Critical parameters include cell density, antibody titer and activation kinetics. Materials 1X sterile PBS Anti-mouse CD3e, Clone 145-2C11 (Functional Grade, Cat. No. 16
Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
Immunohistochemistry using Anti-Ganglioside Antibodies
supernatant containing antiganglioside mAb overnight at 4°C. The time of incubation may range from 30 min. to overnight as determined by experience. 5. Wash with 1% BSA in PBS 4 times. 6. Incubate in FITC-conjugated goat anti-mouse IgM F(ab
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