- ￥980 - 4960
- MedChemExpress(MCE)
- 美国
- HY-129600
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
NUCC-0196361
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2289690-31-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2748.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥980.0 |
| 规格： | 5 mg | 产品价格： | ￥2100.0 |
| 规格： | 10 mg | 产品价格： | ￥3100.0 |
| 规格： | 25 mg | 产品价格： | ￥4960.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
MYCi361
CAS No. : 2289690-31-7
MCE 国际站：MYCi361
产品活性：MYCi361 (NUCC-0196361) 是一种 MYC 抑制剂，其与 MYC 结合的 Kd 为 3.2 μM。MYCi361 (NUCC-0196361) 抑制肿瘤生长并增强 anti-PD1 免疫疗法。
研究领域：Apoptosis
作用靶点：c-Myc
In Vitro: MYCi361 inhibits the viability of MYC-dependent cancer cells including prostate cancer (MycCaP, LNCaP, and PC3), leukemia (MV4-11), lymphoma (HL-60 and P493-6), and neuroblastoma (SK-N-B2) with low-micromolar IC50 values.
In Vivo: MYCi361 inhibits MYC-dependent tumor growth in vivo. MYCi361 treatment (100 mg/kg/day for 2 days; then 70 mg/kg/day for 9 days) induces tumor regression in FVB or NSG male mice.
?MYCi361 has moderate terminal elimination half-life of 44 and 20 h for intraperitoneal (i.p.) or oral (p.o.) dosing in mice, respectively.
?MYCi361 suppresses tumor growth in mice, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy. However, MYCi361 demonstrates a narrow therapeutic index. An improved analog, MYCi975 shows better tolerability.
相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Anti-Cancer Compound Library | Glutamine Metabolism Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Transcription Factor-Targeted Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Mitochondrial Protection Compound Library | 10058-F4 | KJ Pyr 9 | APTO-253 | Idarubicin hydrochloride | MYCMI-6 | EN4 | Mycro 3 | 10074-G5 | KSI-3716 | sAJM589 | BTYNB | Agrimol B | ML327 | Mollugin | hnRNPK-IN-1 | NY2267 | VPC-70619 | WBC100 | Stauprimide | 10074-A4 | IZCZ-3 | IRES-C11 | MYC-RIBOTAC | Chrysomycin A | Lusianthridin | 8α-Tigloyloxyhirsutinolide 13-O-acetate | Anticancer agent 76 | Anticancer agent 84 | BRD4 Inhibitor-15 | BRD4 Inhibitor-18
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
