GB-110

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GB-110 hydrochloride

CAS No. :

MCE 国际站：GB-110 hydrochloride

产品活性：GB-110 hydrochloride 是一种有效的，具有口服活性的，非肽类的 protease activated receptor 2 (PAR2) 激动剂。GB-110 hydrochloride 选择性诱导 PAR2 介导的 HT29 细胞内 Ca²⁺ 释放，EC₅₀ 值为 0.28 μM。

研究领域：GPCR/G Protein

作用靶点：Protease Activated Receptor (PAR)

In Vitro: In an intracellular Ca²⁺ (iCa²⁺) mobilization assay using HT29 colon cancer cells, GB110 (EC₅₀ 240±20 nM; pEC₅₀ 6.7±0.05) is equipotent with the peptide agonist 2f-LIGRLO-NH2 (EC₅₀ 210±30 nM; pEC₅₀ 6.6±0.05), 10-fold more potent than SLIGRL-NH2, but ~35-fold less potent than trypsin (EC₅₀ 6±0.5 nM; pEC₅₀ 8.2±0.8).

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