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- jlcR2753
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- 2025年07月14日
- WB,ELISA等
- 人/动物/植物
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
156
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
CENPA
- 抗体名：
着丝粒蛋白A
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul/200ul/50ul
| 规格： | 100ul | 产品价格： | ¥1580.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ¥2480.0 |
| 规格： | 50ul | 产品价格： | ¥880.0 |
产品货号 : jlcR2753
英文名称 : CENPA
中文名称 : 着丝粒蛋白A
别 名 : CENP A; CENP-A; Centromere autoantigen A; Centromere protein A 17kDa; centromere protein A; centromeric protein A; Histone H3 like centromeric protein A; cenpa; CENPA_HUMAN; Histone H3-like centromeric protein A.
研究领域 : 细胞生物 染色质和核信号 细胞周期蛋白
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用 : WB=1:500-2000 ELISA=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 15kDa
细胞定位 : 细胞核
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human CENPA:65-140/140
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Function:
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
Subunit:
Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interacts (via CATD domain) with HJURP; the interaction is direct and is required for its localization to centromeres. Interacts with CENPC, CENPN and CENPT; interaction is direct. Interacts directly with herpes virus HSV-1 ICP0 protein. Part of a centromere complex consisting of CENPA, CENPT and CENPW.
Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height.
Tissue Specificity:
Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.
Phosphorylation of Ser-7 by AURKA and AURKB during prophase is required for localization of AURKA and AURKB at inner centromere and is essential for kinetochore function. Initial phosphorylation during prophase is mediated by AURKA and is maintained by AURKB.
Poly-ADP-ribosylated by PARP1.
Similarity:
Belongs to the histone H3 family.
SWISS:
P49450
Gene ID:
1058
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CENP-A可将着丝粒变成一个DNA和蛋白的复合物，而且确保着丝粒在细胞分裂中完无损。
CENP-A的存在确保了人体有几乎完全相同的染色体组。
CENP-A功能失常将导致细胞分裂过程中发生染色体分离异常。
CENP-A对于染色体着丝粒的位置起决定作用，因而被认为是重要的表观遗传学标记蛋白。
CENP-A改变了核小体的性状，使得它变得更加坚硬。核小体是由DNA与组合蛋白八聚体构成的真核染色体的一种重复结构，核小体的组织对于基因调控极为重要。不同于染色质上的其他区域。
CENP-A取代组蛋白H3形成核小体，CENP-A核小体重复拷贝形成一个特异的表观遗传区域。
英文名称 : CENPA
中文名称 : 着丝粒蛋白A
别 名 : CENP A; CENP-A; Centromere autoantigen A; Centromere protein A 17kDa; centromere protein A; centromeric protein A; Histone H3 like centromeric protein A; cenpa; CENPA_HUMAN; Histone H3-like centromeric protein A.
研究领域 : 细胞生物 染色质和核信号 细胞周期蛋白
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用 : WB=1:500-2000 ELISA=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 15kDa
细胞定位 : 细胞核
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human CENPA:65-140/140
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Function:
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
Subunit:
Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interacts (via CATD domain) with HJURP; the interaction is direct and is required for its localization to centromeres. Interacts with CENPC, CENPN and CENPT; interaction is direct. Interacts directly with herpes virus HSV-1 ICP0 protein. Part of a centromere complex consisting of CENPA, CENPT and CENPW.
Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height.
Tissue Specificity:
Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.
Phosphorylation of Ser-7 by AURKA and AURKB during prophase is required for localization of AURKA and AURKB at inner centromere and is essential for kinetochore function. Initial phosphorylation during prophase is mediated by AURKA and is maintained by AURKB.
Poly-ADP-ribosylated by PARP1.
Similarity:
Belongs to the histone H3 family.
SWISS:
P49450
Gene ID:
1058
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CENP-A可将着丝粒变成一个DNA和蛋白的复合物，而且确保着丝粒在细胞分裂中完无损。
CENP-A的存在确保了人体有几乎完全相同的染色体组。
CENP-A功能失常将导致细胞分裂过程中发生染色体分离异常。
CENP-A对于染色体着丝粒的位置起决定作用，因而被认为是重要的表观遗传学标记蛋白。
CENP-A改变了核小体的性状，使得它变得更加坚硬。核小体是由DNA与组合蛋白八聚体构成的真核染色体的一种重复结构，核小体的组织对于基因调控极为重要。不同于染色质上的其他区域。
CENP-A取代组蛋白H3形成核小体，CENP-A核小体重复拷贝形成一个特异的表观遗传区域。
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文献和实验相关实验
着丝粒 kinetochore，centromere （1）是染色体的特定的结构部位，在分裂期，着丝粒丝由此部位向纺锤体的两极发展，在中期时，它排列于赤道面上，后期它比染色体的主体先一步向两极进行移动。在许多真核细胞中，其功能局限于染色体的原缢痕部位（称为局限型着丝粒），但在灯芯草科植物的地杨梅属以及半翅目昆虫等生物中没有原缢痕，其功能沿染色体的全长分散着着丝粒。即使是局限型着丝粒，在减数分裂期也往往看不到原缢痕。着丝粒的直径为0.3—0.8微米，是处于光学显微镜的分辨力之内。在局限
着丝粒距离 centromere distance 指在染色体图上某基因与着丝粒之间的距离。在子囊胞子成直线排列于子囊内的某种链孢菌中，因为由减数第二次分裂所产生的子细胞排列在子囊的一端，所以，根据四分体分析可以区别减数第一次分裂分离和减数第二次分裂分离。就以 和a这一对基因来说，四分体的排列若成为（ ， ，a，a）或者（a，a， ， ）的，则为第一次分裂分离，若成为（ ，a， ，a），（a， ，a， ），（ 、a，a， ），（a， ， ，a），则为第二次分裂分离。第二次分裂
着丝粒丝 kinetochore fiber 一般惯称染色体丝，或旧称牵引丝。是纺锤体内在染色体的着丝粒部位和两极之间的丝状结构。染色体丝这一名称容易与构成染色体本身的基本丝状结构相混淆，当然牵引丝在功能上也不能说是确切的名称。着丝粒丝是从前中期开始由着丝粒部位发展起来的。用微分干涉显微镜观察，证明即使在活体的分裂细胞中，着丝粒丝也是客观存在的和具有结构的，在偏光显微镜下，它显示出极为强烈的复折射性。在电子显微镜下，它为直径20毫微米左右的微管束。
着丝粒蛋白A
¥880 - 2480
