- ¥800
- gelatins
- jlcR1993
- 国内
- 2025年07月13日
- WB,ELISA等
- 人/动物/植物
10 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
154
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
MUC2
- 抗体名：
粘蛋白-2/上皮膜抗原2抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
500ug
产品货号 : jlcR1993
英文名称 : MUC2
中文名称 : 粘蛋白-2/上皮膜抗原2抗体
别 名 : MLP; SMUC; Intestinal mucin 2; MUC 2; MUC2; Mucin 2; Mucin 2 intestinal; Mucin 2 intestinal/tracheal; Mucin 2 oligomeric mucus/gel forming; Mucin 2 precursor; Mucin 2 tracheal; Mucin like protein; Mucin2; Intestinal mucin-2; MUC-2; Muc2; MUC2_HUMAN; Mucin-2; Mucin2.
研究领域 : 肿瘤 细胞生物 免疫学 细胞粘附分子 糖蛋白 肿瘤细胞生物标志物 细胞外基质
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat,
产品应用 : ELISA=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 570kDa
细胞定位 : 分泌型蛋白
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human Muc2:4901-5179/5179
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Function:
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Subunit:
Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked.
Subcellular Location:
Secreted. Note=In the intestine, secreted into the inner and outer mucus layers.
Tissue Specificity:
Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
Post-translational modifications:
O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
Similarity:
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 TIL (trypsin inhibitory-like) domain.
Contains 2 VWFC domains.
Contains 4 VWFD domains.
SWISS:
Q02817
Gene ID:
4583
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞粘附蛋白（Call Adhesion Protein）
上皮膜抗原是粘性糖蛋白家族之一,是一种膜内在糖蛋白。Muc-2表达仅限于内膜腺上皮和腔上皮,很多上皮细胞及其来源的肿瘤表达该蛋白.其合成和分泌是腺上皮组织的特征之一。MUC-2也是一种主要的肠道粘蛋白，在正常肠道和结肠癌、胃癌等肿瘤中有广泛分布。该抗体主要用于胃肠道肿瘤的研究。
英文名称 : MUC2
中文名称 : 粘蛋白-2/上皮膜抗原2抗体
别 名 : MLP; SMUC; Intestinal mucin 2; MUC 2; MUC2; Mucin 2; Mucin 2 intestinal; Mucin 2 intestinal/tracheal; Mucin 2 oligomeric mucus/gel forming; Mucin 2 precursor; Mucin 2 tracheal; Mucin like protein; Mucin2; Intestinal mucin-2; MUC-2; Muc2; MUC2_HUMAN; Mucin-2; Mucin2.
研究领域 : 肿瘤 细胞生物 免疫学 细胞粘附分子 糖蛋白 肿瘤细胞生物标志物 细胞外基质
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat,
产品应用 : ELISA=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 570kDa
细胞定位 : 分泌型蛋白
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human Muc2:4901-5179/5179
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Function:
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Subunit:
Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked.
Subcellular Location:
Secreted. Note=In the intestine, secreted into the inner and outer mucus layers.
Tissue Specificity:
Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
Post-translational modifications:
O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
Similarity:
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 TIL (trypsin inhibitory-like) domain.
Contains 2 VWFC domains.
Contains 4 VWFD domains.
SWISS:
Q02817
Gene ID:
4583
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞粘附蛋白（Call Adhesion Protein）
上皮膜抗原是粘性糖蛋白家族之一,是一种膜内在糖蛋白。Muc-2表达仅限于内膜腺上皮和腔上皮,很多上皮细胞及其来源的肿瘤表达该蛋白.其合成和分泌是腺上皮组织的特征之一。MUC-2也是一种主要的肠道粘蛋白，在正常肠道和结肠癌、胃癌等肿瘤中有广泛分布。该抗体主要用于胃肠道肿瘤的研究。
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验相关实验
腹腔（abdominal cavity）是壁腹膜与脏腹膜互相延续移行，形成的一个不规则、潜在性的囊状间隙。覆盖于腹盆壁和腹盆腔器官表面的浆膜，薄而光滑，由单层扁平上皮和结缔组织构成腹膜。腹腔内有腹膜腔内浆液量并非是固定不变的，而是产生与吸收处于动态平衡。在病理情况下可产生较多的液体，称腹腔积液（peritoneal effusion）或腹水（ascites）。根据积液的性质和形成的原因分为渗出液和漏出液两大类，区分积液的性质及良、恶性积液对疾病的诊断和治疗有重要意义
删除突变的drs基因分析揭示，C末端区以及3个一致重复的N末端区都出现凋亡。Caspase-12、Caspase –9以及Caspase-3都继续被drs激活，Caspase--3,和Caspase-9的抑制剂都抑制drs引起的凋亡。在凋亡过程中没有看到因drs引起线粒体细胞色素C释放到细胞质去，这表明线粒体途径不是drs介导的凋亡，而且，研究人员发现，Drs蛋白能与定位在内质网的凋亡蛋白ASY/Nogo-B/RTN-x(S)结合，并且这些基因共同表达增加了凋亡的效果。这项研究结果提示，由ASY
44.8岁，PHG患者6例，合并消化性溃疡的PHG患者7例。②法莫替丁组：共14例，男13例，女1例，平无年龄45.6岁，PHG患者7例，合并消化性溃疡的PHG患者7例。 疗效判断 ①PHG的胃粘膜改变分3级：好转：胃粘膜皱襞红肿渗出血灶完全消失；改善：局限于胃窦、体或底部一个区域的胃粘膜皱襞轻度细微红色样斑点灶，无剥脱感；无效：胃粘膜仍无明显变化。②幽门螺杆菌清除：胃粘膜活检经W－S银染色在光学显微镜下未见细菌。③溃疡愈合：内镜下溃疡消失或瘢痕形成。④症状缓解情况：上腹疼痛、腹胀、乏力
粘蛋白-2/上皮膜抗原2抗体
¥800
