- 询价
- Cell Signaling Technology
- 3666
- USA
- 2025年12月17日
- W
- Rabbit
- H,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Annexin A7 Antibody
- 抗原：
synthetic peptide corresponding to residues near the carboxy terminus of human annexin A7
- 应用范围：
W
- 宿主：
Rabbit
- 库存：
大量
- 供应商：
CST
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 适应物种：
H,Mk
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H Mk | Endogenous | 47, 51 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Annexin A7 Antibody detects endogenous levels of total annexin A7 protein, including isoforms 1 and 2. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human annexin A7. Antibodies are purified using protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from U251, SHSY-5Y and COS cells using Annexin A7 Antibody. |
| Background | Annexin A7/ANXA7 is a member of the annexin family of calcium/phospholipid-binding proteins, and is involved in the process of membrane fusion and exocytosis (1). Annexin A7 is a GTPase, and both GTP-binding and PKC activity are important in regulating protein function (2,3). Membrane binding of annexin A7 is calcium dependent (4). Two isoforms exist due to alternative splicing. Subcellular localization of annexin A7 has been shown to be in the cytoplasm, vesicular structures, membrane and in adrenal chromaffin granules (5,6). Nuclear localization has been shown in the developing mouse central nervous system as well as in adult mouse brain (7). Annexin A7-deficient mouse studies show that the protein has a role in insulin secretion and calcium signaling (8) as well as cardiac intracellular calcium homeostasis electrical stability (9). The gene for annexin A7 is a putative tumor suppressor (10), and alterations in the copy number have been reported in prostate cancer (11). Annexin A7 expression has also been correlated with survival in human glioblastoma patients (12), and haploinsufficiency in mice may promote genetic instability leading to tumorigenesis (13).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验祝贺〖雅裕睿安〗成为Signalway Antibody(SAB)独家
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Biotinylation of Antibody ( Contributed by Nanci Donacki ) Antibody labeling (House Ear Institute)Labeling protocols using affinity markers. Coupling Colloidal Gold to Protein (Walter Steffen)Gold labelling of rabbit IgGPreparation
Biosynthetic labeling (Sefton Lab) Biotinylation of Antibody (Contributed by Nanci Donacki) 125 I Labeling of Protein using ICl (ScienceXchange) Protein (Antibody) Fluorescent Labeling (Mario Roederer) Gives detailed
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