- 询价
- Cell Signaling Technology
- 2590
- USA
- 2025年12月16日
- W, IP, IF-IC
- Rabbit
- H
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
SirT6 Antibody
- 抗原：
synthetic peptide corresponding to the carboxy terminus of the human SirT6 protein
- 应用范围：
W, IP, IF-IC
- 宿主：
Rabbit
- 适应物种：
H
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 供应商：
CST
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IF-IC | H | Endogenous | 42 | Rabbit |
| Protocols | |
|---|---|
| Specificity / Sensitivity | SirT6 Antibody detects endogenous levels of total SirT6 protein. This antibody does not cross-react with other sirtuin proteins. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of the human SirT6 protein. Antibodies are purified by peptide affinity chromatography. Western Blotting
Western blot analysis of various cell types using SirT6 Antibody. IF-IC
Confocal immunofluorescent analysis of HeLa cells using SirT6 Antibody (green). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). |
| Background | The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as Class III histone deacetylases. The first discovered and best characterized of these genes is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response and cell aging (1). SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway (2-4). The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2 O2 (2). In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres and gaps (2). SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway (2). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验检验技士辅导:SIRT6酶延缓细胞衰老 美国斯坦福大学的研究小组最近发现，去乙酰化酶sirtuin家族成员之一SIRT6可能对延缓衰老起关键作用，以前人们一直认为，只有其“亲属”SIRT1才与衰老有关。研究人员还首次证明sirtuin能调控基因活动。该研究发表在最新一期的《细胞》杂志上。 研究小组发现，失去SIRT6的老鼠刚开始几周内能正常生长，但之后会很快衰老，并在几个月后死于低血糖。 该研究小组曾在去年证明
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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