- 询价
- Cell Signaling Technology
- 3606
- USA
- 2025年12月13日
- W
- Rabbit
- H,M,R
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
NCAM (CD56) Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding amino acid 800 of human NCAM
- 应用范围：
W
- 宿主：
Rabbit
- 库存：
大量
- 供应商：
CST
- 适应物种：
H,M,R
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R | Endogenous | 140 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | NCAM (CD56) Antibody detects endogenous levels of total NCAM protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding amino acid 800 of human NCAM. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from human cerebellum and rat brain, using NCAM (CD56) Antibody. |
| Background | NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains (1). NCAM mediates neuronal attachment, neurite extension and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma and rhabdomyosarcoma (2). CD56 and CD16 are commonly used to identify NK cells although some cells with the T cell markers CD3 and CD4 also express CD56 (3). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验CD56 分子 CD56 常用单克隆抗体或代号： Leu19,NKH1;(NCAM) 主要表达细胞： NK,Tsub [NK] 分子质量(kDa)和结构： gp180(GPI连接,含FN结构域, 功 能：神经细胞粘附分子(N- CAM) 粘附,诱导杀伤活性 CD56 Aka N-CAM (neural cell adhesion molecule), at #11q23 Regulates homophilic
，是一个潜在的NK细胞marker。4. lnc-CD56生物学功能研究在dNK细胞中，lnc-CD56与CD56表达正相关，那么lnc-CD56是否正向调控了CD56？因此，研究人员在HEK-293T细胞中用shRNA敲降了lnc-CD56。结果显示，CD56/NCAM1的mRNA表达水平下降。当在CD34+HPCs中转染敲降lnc-CD56载体，研究人员发现CD56+ 的NK细胞数量减少，CD56的荧光表达也减弱。进一步通过nuclear runon实验验证，lnc-CD56的敲降直接影响了CD56
。PECAM-1表达于约50％的外周血淋巴细胞，并高水平表达于内皮细胞，尤在内皮细胞连接处。PECAM是一种同型黏附分子，还可与整合素αVβ3结合，参与单核细胞、中性粒细胞、NK细胞和活化T细胞穿出毛细血管壁的过程。 (2)NCAM-1(CD56)：NCAM-1是神经细胞黏附分子(neuralCAM-1)的缩写，分子胞膜外区有5个IgSFC2样结构域．近膜区有2个FN3结构域。NCAM-1表达于人NK细胞和某些T细胞，以及神经、肌肉和多种胚胎组织，甚至多种肿瘤细胞。NCAM
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