- 询价
- Cell Signaling Technology
- 3088
- USA
- 2025年12月24日
- W, IP
- Rabbit
- H,M,R,Mk,Hm,C,X,B,Dg,Pg,GP,Hr
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
TH1L Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Ala132 of human TH1L protein
- 应用范围：
W, IP
- 宿主：
Rabbit
- 适应物种：
H,M,R,Mk,Hm,C,X,B,Dg,Pg,GP,Hr
- 库存：
大量
- 保质期：
详见说明书
- 供应商：
CST
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Hm=Hamster Mk=Monkey C=Chicken X=Xenopus B=Bovine Dg=Dog Pg=Pig GP=Guinea Pig Hr=Horse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M R Mk (Hm) (C) (X) (B) (Dg) (Pg) (GP) (Hr) | Endogenous | 66 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | TH1L Antibody recognizes endogenous levels of total TH1L protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala132 of human TH1L protein. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from various cell lines using TH1L Antibody. |
| Background | Negative Elongation Factor (NELF) consists of four subunits: WHSC2 (NELF-A), COBRA-1 (NELF-B), TH1L (NELF-C/D), and NELF-E (1). NELF, together with DRB-sensitivity inducing factor (DSIF), inhibits RNA Polymerase II (RNAPII) elongation resulting in RNAPII promoter proximal pausing, where it awaits additional signaling to resume transcription (2,3). The release of this promoter proximal pausing of RNAPII is a critical regulatory point during transcription and is signaled by phosphorylation of the C-terminal domain (CTD) within the largest subunit of RNAPII and NELF by positive transcription elongation factor (P-TEFb) (4,5). WHSC2 is thought to connect the NELF complex to RNAPII machinery, while NELF-E contains an RNA binding motif that is necessary for NELF function (1,6,7). TH1L, together with COBRA-1, help bring WHSC2 and NELF-E together and are integral subunits of the NELF complex (1). In addition to its role in transcription regulation, TH1L is a negative regulator of MAPK signaling by inhibiting A-Raf and PAK1 kinase activities. Research studies have shown that TH1L expression is negatively correlated with breast cancer proliferation and migration (8-10).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease
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