- 询价
- Cell Signaling Technology
- 5754
- USA
- 2025年11月19日
- W, IP
- Rabbit
- H,M,Mk
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- 详细信息
- 技术资料
- 抗体英文名：
RCHY1 Antibody
- 抗原：
synthetic peptide corresponding to residues near the carboxy terminus of human RCHY1 protein isoform1
- 应用范围：
W, IP
- 宿主：
Rabbit
- 库存：
大量
- 供应商：
CST
- 级别：
详见MSDS文件
- 适应物种：
H,M,Mk
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M (Mk) | Endogenous | 29 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | RCHY1 Antibody detects endogenous levels of total RCHY1 protein. This antibody does not detect RCHY1 dimers. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human RCHY1 protein isoform1. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from various cell lines using RCHY1 Antibody. Western Blotting
Western blot analysis of extracts from 293T cells, either mock transfected or transfected with a construct overexpressing murine RCHY1, using RCHY1 Antibody. |
| Background | R ING finger and CHY1 zinc finger domain-containing protein 1 (RCHY1 ) is a newly identified RING-H2-type protein-ubiquitin E3 ligase that is expressed as multiple isoforms generated through alternative splicing of mRNA transcripts (1,2). Notably, RCHY1 is a p53-regulated gene and multiple studies have shown that RCHY1 directly binds p53 to promote its ubiquitin-dependent proteasomal degradation, ultimately leading to repression of p53 growth suppressive transcriptional activity (1,3). RCHY1 is also likely to promote deregulated cell proliferation by targeting the CDK inhibitor, p27 Kip1, for proteasomal degradation (4). In agreement with its growth promoting activity, RCHY1 overexpression has been linked to cancer of the lung (5,6) and prostate (7).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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