- 询价
- Cell Signaling Technology
- 4892
- USA
- 2025年08月29日
- W, IF-IC
- Rabbit
- H,C
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
p63-α Antibody
- 抗原：
synthetic peptide corresponding to residues within the carboxy-terminus of p63alpha
- 应用范围：
W, IF-IC
- 宿主：
Rabbit
- 适应物种：
H,C
- 供应商：
CST
- 库存：
大量
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human C=Chicken
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IF-IC | H (C) | Endogenous | 75 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | p63alpha Antibody detects endogenous levels of total p63alpha protein. This antibody will detect both full length TAp63alpha and truncated deltaNp63alpha, but not p63beta or p63gamma. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues within the carboxy-terminus of p63alpha. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from ME-180 cells, using p63α Antibody. IF-IC
Confocal immunofluorescent analysis of A-431 cells (left) and MCF7 cells (right) using p63-α Antibody (green). Actin filaments were labeled with DY-554 phalloidin (red). |
| Background | The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in both structure and function (2). While p63 can induce p53-responsive genes and apoptosis, mutation of p63 rarely results in tumors (2). Amplification of the p63 gene is frequently observed in squamous cell carcinomas of the lung, head and neck (2,3). The p63 gene contains an alternative transcription intiation site that yields a 40 kDa deltaNp63 lacking the transactivation domain, and alternative splicing at the carboxy-terminus yields the alpha, beta and gamma isoforms (3,4).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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