- 询价
- Cell Signaling Technology
- 9534
- USA
- 2025年10月30日
- W
- Rabbit
- H,M,R,Pg
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
Acetyl-β-Catenin (Lys49) Antibody
- 抗原：
synthetic acetylated peptide corresponding to residues surrounding Lys49 of human β-catenin
- 应用范围：
W
- 宿主：
Rabbit
- 供应商：
CST
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 适应物种：
H,M,R,Pg
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H (M) (R) (Pg) | Endogenous | 92 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Acetyl-β-Catenin (Lys49) Antibody detects endogenous β-catenin only when acetylated at Lys49. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic acetylated peptide corresponding to residues surrounding Lys49 of human β-catenin. Antibodies were purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of total cell lysates from 293 cells, untransfected or transiently transfected with a construct expressing CBP, using Acetyl-β-Catenin (Lys49) Antibody (Top), or total β-Catenin Antibody (Amino-terminal Antigen) #9581 (Bottom). |
| Background | β-catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3 (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8). Lys49 lies in a region that contains several Ser/Thr residues whose phosphorylation status regulates the stability of β-catenin and is one of few residues frequently mutated in thyroid anaplastic carcinoma (9). CBP (CREB-binding protein) binds and acetylates β-catenin at Lys49 (10, 11).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Conjugation of Antibody to HRP
:EDTA Add 0.25 g NaOH pellets to this solution to neutralize to approximately pH 7.0 Add to antibody solution at 6.49 ml/ml SATA. Gently stir for 30 minutes at room temperature. Equilibrate column with PBS:EDTA. Desalt thiolated antibody
dongreyuan 有的抗体名称上面写着Ab-33，比如，β-catenin（Ab-33）antibody，请问，Ab-33是什么意思？ bettyzyj 这个抗体是非磷酸化的抗体non-phospho-antibody ，33 代表的是基因位点 dongreyuan 谢谢了 yhwangcams bettyzyj wrote
祝贺〖雅裕睿安〗成为Signalway Antibody(SAB)独家
、 Wnt 通道 /β- 连环素等领域提供最优质的产品。 Signalway Antibody(SAB)( 美国)多年来一直致力于磷酸化蛋白抗体的研发，生产和销售。公司拥有抗磷酸化蛋白抗体库产业化大规模技术平台，处于国内领先，国际先进水平。公司建立了一整套完善的生产、质量控制、产品保存、运输及销售的管理体系。 公司现已在美洲、欧洲和亚洲成立了销售中心，产品销往美国、英国、德国、日本等40多个国家，受到广泛好评。
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