- 询价
- Cell Signaling Technology
- 2137
- USA
- 2025年10月24日
- W, IP
- Rabbit
- H,M
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
AFP Antibody
- 抗原：
synthetic peptide corresponding to amino acids near the carboxy terminus of human AFP
- 应用范围：
W, IP
- 宿主：
Rabbit
- 库存：
大量
- 供应商：
CST
- 适应物种：
H,M
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M | Recombinant | 70 kDa | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | AFP Antibody detects recombinant human and mouse AFP protein. The antibody can only immunoprecipitate human AFP. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids near the carboxy terminus of human AFP. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of recombinant AFP, using AFP Antibody. |
| Background | Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the serum of the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells (1,2). The tumor suppressor gene p53 and β-catenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Elevated serum levels are predictive of hepatocellular carcinoma (3). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验性质：AFP是胚胎时期的重要血清成分，由卵黄囊和肝细胞合成，胎儿出生后，其浓度急剧下降，几个月至一年可降至正常水平，正常值小于20μg/L. 临床意义： 成人血清AFP增高见于： （1）原发性肝细胞癌：有辅助诊断，早期诊断，鉴别诊断的意义，动态观察，AFP不高者不能排除原发性肝癌。 （2）生殖系统胚胎瘤：恶性畸胎瘤。医学教育|网搜集整理 （3）消化道癌有部分增高。 （4）消化道肿瘤肝转移。 （5）妊娠，急、慢性肝炎，肝硬化有一过
Gene Targeting to Hepatomas (AFP)
Hepatocellular carcinoma (HCC) is one of the most common malignancies with poor prognosis worldwide, especially in eastern Asia and Africa (1 ). Recent advances in delivering genes to mammalian cells stimulate the possibility of gene therapy
AFP生化检查： 性质： AFP是胚胎时期的重要血清成分，由卵黄囊和肝细胞合成，胎儿出生后，其浓度急剧下降，几个月至一年可降至正常水平，正常值小于20μg/L.临床意义： 成人血清AFP增高见于： （1）原发性肝细胞癌：有辅助诊断，早期诊断，鉴别诊断的意义，动态观察，AFP不高者不能排除原发性肝癌。 （2）生殖系统胚胎瘤：恶性畸胎瘤医`学教育网搜集整理。 …… 点击查看：bbs.med66.com/forum-267-250
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